人表皮生长因子受体-2在胃癌组织中的表达及意义  

Clinical significance of HER-2 protein expression in Human Gastric Carcinoma

作　　者：刘莉[1] 姜勇[2] 李丽[2] 刘都礼[1] 

机构地区：[1]成都大学附属医院病理科,四川成都610081 [2]四川大学华西医院病理科,四川成都610041

出　　处：《实用医院临床杂志》2012年第5期155-157,共3页Practical Journal of Clinical Medicine

基　　金：四川省卫生厅科研基金资助项目(编号:100077)

摘　　要：目的探讨胃癌组织中人表皮生长因子受体-2(human epidermal growth factor receptor 2,HER-2)的表达及与临床病理特征的关系。方法应用免疫组化Envision二步法检测70例胃癌组织中HER-2的表达情况,并结合其临床病理特点进行分析。结果 HER-2在胃癌组织中的阳性表达率为27.1%(19/70),阳性过表达率为15.7%(11/70)。阳性表达与肿瘤分化程度、侵袭深度、有无淋巴结转移及TNM分期有关(P<0.05),而与患者的性别、年龄、肿瘤部位和大小无关(P>0.05)。结论 HER-2的表达参与胃癌的生长、侵袭和转移过程。检测HER-2有助于筛选对曲妥珠单抗(Herceptin)靶向治疗敏感的胃癌患者,也为胃癌的预后判断提供客观的参考指标。Objective To investigate the correlation between HER-2 protein expression and clinicopathological factors of gastric carcinoma. Methods HER-2 protein expression was detected by immunohistochemistry（Envision） in 70 gastric carcinoma specimens, and the corresponding clinical and pathological characteristics were also analyzed. Results The positive rate of HER-2 protein expression was 27.1% （19/70）. HER-2 over-expression rate was 15.7% （11/70）. HER-2 protein expression was associated with the tumor differentiation, invasion depth, lymph note metastasis and TNM stage （P 〈 0.05 ）, hut not with sex, age, tumor site and tumor size （P 〉 O. 05 ）. Conclusion HER-2 expression may participate in the development,invasion and metastasis of gastric carcinoma. Detec- ting the HER-2 status is a prerequisite of？ trastuzumab monoclonal antibody（Herceptin） therapy for gastric carcinoma, and can assess the malignant biological behaviors and prognosis of gastric carcinoma.

关 键 词：胃癌 表皮生长因子受体-2 免疫组织化学 

分 类 号：R341[医药卫生—基础医学] R735.2