妊娠高血压疾病患者治疗前后血浆炎症因子的变化  

The changes of plasma inflammatory cytokines in patients with pregnancy-induced hypertension syndrome before and after treatment

作　　者：石军 罗利飞[2] 

机构地区：[1]浙江省余姚市第四人民医院妇产科,浙江余姚315470 [2]浙江省台州医院路桥院区检验科,浙江台州318050

出　　处：《中国现代医生》2012年第23期16-17,共2页China Modern Doctor

基　　金：2008年浙江省台州市科技计划项目(081KY39)

摘　　要：目的观察妊娠高血压疾病(PIH)患者治疗前后血浆炎症因子水平的变化。方法对50例PIH患者(观察组)治疗前后的高敏C反应蛋白(hs-CRP)、血浆肿瘤坏死因子-α(TNF-α)、白介素-6(IL-6)、白介素-10(IL-10)水平进行测定,另选择30例正常妊娠孕妇作为对照组。结果观察组的血浆IL-10水平明显低于对照组,hs-CRP、TNF-α和IL-6水平明显高于对照组(P<0.01)。治疗1周后,观察组的血浆IL-10水平均较治疗前明显上升,hs-CRP、TNF-α和IL-6水平较治疗前明显降低(P<0.01)。结论 PIH患者体内存在血浆炎症因子平衡失调。通过调节血浆炎症因子的水平,可为PIH防治提供一种新的方法。To observe the changes of plasma inflammatory cytokines in patients with PIH （pregnancy-induced hypertension syndrome） before and after treatment. Methods A total of 50 cases of PIH patients （observation group） were tested for plasma hs-CRP, TNF-α, IL-6 and IL-10 levels before and after treatment, and another 30 cases with normal pregnancy admitted to hospital were selected as control group. Results The plasma IL-10 level of the observation group were significantly lower than those of the control group, and hs-CRP, TNF-α and IL-6 levels were significantly higher （all P 〈 0.01）. One week after treatment, plasma IL-10 level increased significantly compared with those before treatment in observation group, hs-CRP, TNF-α and IL-6 levels were significantly lower than those before treatment （all P 〈 0.01）. Conclusion There is disturbance in plasma cytokines in PIH patients. It provides a new approach for the prevention and treatment of patients with PIH through correcting the plasma inflammatory cytokines imbalance.

关 键 词：妊娠高血压疾病 高敏C反应蛋白 肿瘤坏死因子-α 白介素-6 白介素-10 

分 类 号：R714.246[医药卫生—妇产科学]