炎症细胞因子在COPD患者治疗前后的变化  

Changes of plasma cytokines in patients with chronic obstructive pulmonary disease before and after treatment

作　　者：叶军辉 余贤广 凌杰[2] 

机构地区：[1]浙江省三门县人民医院呼吸内科,浙江三门317100 [2]浙江省台州市第一人民医院检验科,浙江台州318020

出　　处：《中国现代医生》2012年第23期29-30,共2页China Modern Doctor

基　　金：2006年浙江省台州市科技计划项目(第一批)(061KY68)

摘　　要：目的探讨炎症细胞因子在慢性阻塞性肺疾病患者治疗前后的变化。方法选择45例急性发作期的COPD患者(观察组),入院后予以吸氧、抗感染、止咳化痰及平喘等常规对症治疗1周。观察治疗前后血浆肿瘤坏死因子-α(TNF-α)、转化生长因子(TGF-β1)和白介素-10(IL-10)水平的变化。另选择我院体检中心正常的健康体检者30例作为对照组。结果观察组的血浆TNF-α和TGF-β1水平明显高于对照组,IL-10水平明显低于对照组(均P<0.01);治疗1周后,观察组的血浆TNF-α和TGF-β1水平较治疗前明显下降,血浆IL-10水平较治疗前明显上升(均P<0.01)。结论 TNF-α、TGF-β1和IL-10参与了COPD发病过程,通过调节血浆炎症细胞因子的水平,为COPD治疗提供新的思路。Objective To explore the changes of plasma cytokines in patients with chronic obstructive pulmonary disease before and after treatment. Methods Forty-five patients with COPD in acute stage were choosed as observing group, and all patients got treatments as oxygen, antibiotics, drugs for relieving cough, sputum and asthma, and other symptomatic and supportive treatment for 1 week. The plasma levels of TNF-α, TGF-β1 and IL-IO were observed before and after treat ment. 30 normal people were choosed as control group. Results The levels of TNF-α and TGF-β1 of observing group were significantly higher than that of control group, hut the level of IL-10 was the opssite （all P 〈 0.01）. 1 week after treatment, compared to that before treatment, the levels of TNF-α and TGF-β1 of observing group descended significantly, and the level of IL-10 rised significantly （all P 〈 0.01）. Conclusion TNF-α, TGF-β1 and IL-10 participate in the progress of COPD. Maybe it is a new thinking to treat the COPD by regulating the level of cytokines.

关 键 词：慢性阻塞性肺疾病 肿瘤坏死因子-Α 转化生长因子-Β1 白介素-10 

分 类 号：R563.9[医药卫生—呼吸系统]