达因-35及二甲双胍预处理对肥胖型多囊卵巢综合征促排卵治疗的影响  

The therapeutic effect of the Dyne-35 and pretreatment of metformin on obese polycystic ovary syndrome promoting ovulation

作　　者：李雅琪[1] 彭俊[1] 张瑜[1] 马燕[1] 宋致蓉 廖国芳[1] 杨炜婷 

机构地区：[1]凉山州第一人民医院妇产科,四川西昌615000

出　　处：《疑难病杂志》2012年第9期684-686,共3页Chinese Journal of Difficult and Complicated Cases

摘　　要：目的探讨达因-35及二甲双胍预处理对肥胖型多囊卵巢综合征患者促排卵的临床效果。方法 40例多囊卵巢综合征患者随机分为2组,观察组22例给予达因-35联合二甲双胍治疗,对照组18例只给予达因☆5治疗,疗程均3个月,2组给予氯米芬及HCG促排卵,观察治疗前后内分泌相关指标、排卵及妊娠等情况。结果观察组治疗后体质量指数均明显降低(P<0.05)。观察组除空腹血糖外,空腹胰岛素、血糖及胰岛素曲线下面积(AUC)、胰岛素抵抗指数(HOMA-IR)水平治疗后均明显下降(P<0.05),与对照组比较差异有统计学意义(p<0.05);2组患者治疗后LH、T及LH/FSH比值均有明显改善,但观察组改善较对照组更明显(P<0.05);观察组排卵率为68.2%,妊娠率为40.9%,优于对照组的排卵率50.0%、妊娠率27.8%(P<0.05)。结论达因-35联合二甲双胍对降低肥胖型多囊卵巢综合征雄激素水平,改善胰岛素抵抗,提高排卯及妊娠率有明显效果。Objective To study the effect on obese polycystic ovary syndrome with metformin Dyne-35 and observe clinical effect on ovulation.Methods 40 cases of polycystic ovarian syndrome were enrolled and divided into two groups,experimental group（n = 22） were given Dyne 35 and metformin treated for 3 months,control group（n =18） only treated with metformin for 3 months.Clomiphene and HCG were given then in both groups,effect on endocrine related indicators,before and after ovulation and pregnancy were observed.Results BMI were decreased in experimental group（P 〈0.05）.Except fasting blood glucose,all other indexes included fasting insulin,AUC（blood glucose）,and AUC（insulin）,and HOMA-IR level were decreased obviously（P 〈0.05）,and there were significant differences between the two group（P 〈0.05）.LH, T and LH/FSH ratio were improved in both groups,but experimental group were better than control group（P 〈0.05）.Experimental group ovulation rate was 68.2%,pregnancy rate was 40.9%,which were better than control group of ovulation rate 50.0%,pregnancy rate 27.8%（P 〈0.05）.Conclusion Dyne-35 combined with metformin can reduce androgen levels in obese polycystic ovary syndrome,improve insulin resistance,ovulation and pregnancy rates.

关 键 词：达因-35 二甲双胍 多囊卵巢综合征 肥胖型 促排卵 

分 类 号：R711.75[医药卫生—妇产科学]