丹黄凝胶体外释放和经皮渗透特性考察  

Investigation of in vitro Release and Transdermal Permeability Characteristics of Danhuang Gel

作　　者：程建明[1] 陈新民[1] 彭稳稳[1] 李俊松[1] 李文[2] 

机构地区：[1]南京中医药大学,南京210029 [2]江苏省南京市中医院,南京210001

出　　处：《中国实验方剂学杂志》2012年第18期24-26,共3页Chinese Journal of Experimental Traditional Medical Formulae

基　　金：江苏省中医药局科技项目(LB09081)

摘　　要：目的:研究丹黄凝胶体外释药特性和体外经皮渗透性。方法:采用改良Franz扩散池,以大黄酚、小檗碱为评价指标,运用动力学模型描述指标成分在体外的释药规律和经皮渗透规律。结果:大黄酚以零级动力释放模型拟合优度最好,小檗碱以Ritger-Peppas模型拟合优度最好;大黄酚和小檗碱在体外皮肤均以一级动力学渗透吸收;大黄酚、小檗碱体外释药特性与经皮渗透性的相关方程分别为Y=0.468 7X+4.972 2(r=0.966 4),Y=0.666 9X+2.487 4(r=0.974 0),体外释放速率均>体外经皮速率。结论:大黄酚、小檗碱体外释药特性与经皮渗透性存在较好线性相关性。Objective： To study on characteristics of in vitro release and transdermal penetration of Danhuang gel. Method： Modified Franz diffusion cell was used, with berberine and chrysophanol as indexes, in vitro drug release and percutaneous penetration laws of index components were described by kinetic model. Result： Release of chrysophanol could be fitted best by zero-power kinetics model, but berberine by Ritger-Peppas model; Penetration of chrysophanol and berberine in vitro skin were best by fitting for one-power kinetics model; Relevant linear equation of in vitro＇release and transdermal penetration for chrysophanol could be described as Y = 0. 468 7X ＋4. 972 2 （r =0. 966 4）, berberine as Y=0. 666 9X ＋2. 487 4 （r =0. 974 0）, and in vitro release rate was higher than in vitro transdermal rate of two index components in Danhuang gel. Conclusion： In vitro release and transdermal penetration of berberine and chrysophanol had a good linear correlation.

关 键 词：丹黄凝胶 体外释放 经皮渗透 大黄酚 小檗碱 

分 类 号：R283.6[医药卫生—中药学]