左旋氨氯地平联合丹参冻干粉针防治冠脉支架内再狭窄  

Effect of Levam Lodipine and Salvia Miltiorrhiza Freeze-dried Powder Injection Combination on in-Stentrestenosis after Intracoronary Stenting

作　　者：童珊珊[1] 吴峻[1] 肖云[1] 李钰青[1] 佘晓芬[1] 

机构地区：[1]广州医学院第一附属医院心内科,广州510120

出　　处：《中国实验方剂学杂志》2012年第18期287-291,共5页Chinese Journal of Experimental Traditional Medical Formulae

基　　金：广东省省科技计划(2009B080701033)

摘　　要：目的:研究左旋氨氯地平和丹参冻干粉联合防治冠脉支架内再狭窄的临床价值。方法:收集并回顾性研究本院进行冠脉内支架植入术成功的冠心病患者血浆标本222例,分为对照组、丹参冻干粉针组、左旋氨氯地平组和联合组用药组(左旋氨氯地平+丹参冻干粉针,观察对术前、后和随访6个月经冠脉造影(CAG),并测定血浆中术后和随访6个月的内皮素(endothelin,ET)、一氧化氮(nitrogen monoxide,NO)、甘油三酯(triglyceride,TG)、血清总胆固醇(serum total cholesterol,TC)的水平。结果:与对照组相比,丹参冻干粉组、左旋氨氯地平组的再狭窄率降低,但无统计学差异,而联合组的再狭窄率降低并且有统计学意义。丹参冻干粉组、左旋氨氯地平组、联合组TG,TC均降低,且左旋氨氯地平组、联合组ET降低,NO升高(P<0.05)。结论:丹参冻干粉和左旋氨氯地平两者联合使用对支架内再狭窄(IRS)的发生有预防作用。Objective：To evaluate the effect of Levam Lodipine and Salvia Miltiorrhiza Freeze-dried powder injection combination on in-stentrestenosis after intracoronary stenting.Method：Two hundreds and Twenty-two coronary heart disease patients with successful intracoronary stenting were divided randomly into the control group,the group of Salvia Miltiorrhiza Freeze-dried powder injection,the group of Levam Lodipine and the group of combination（Levam Lodipine plus Salvia Miltiorrhiza Freeze-dried powder injection）.Coronary angiograhpic（CAG） was made in patients with the angiograms of post-intervention and 6 months after treatment for all group.And serum（endothelin） ET,（nitrogen monoxide）NO,（triglycerid）TG and（serum total cholestero）TC were detected in patients with the angiograms of post-intervention and 6 months after treatment for all group.Result：In-stent restenosis（ISR） rate was significant decreased in the group of combination（P〈0.05）.The serum TC and TG levels were decreased in the group of Salvia Miltiorrhiza Freeze-dried powder injection,the group of Levam Lodipine and the group of combination.The serum ET level was decreased in the group of Levam Lodipine and the group of combination,while the NO levels was increased（P〈0.05）.Conclusion：Both Salvia Miltiorrhiza Freeze-dried powder injection and Levam Lodipine has benefit for preventing restenosis after intracoronary stenting.

关 键 词：左旋氨氯地平 丹参冻干粉针 冠脉支架内再狭窄 

分 类 号：R287[医药卫生—中药学]