胱抑素C对3～6个月龄孕妇妊高征的预测价值分析  

Analysis on Predictive Value of Cystatin C on Pregnancy Hypertension Syndrome of 3-6 Months

作　　者：李祥顺[1] 黄梅霞[1] 张秋莹[1] 杨生宙[1] 何景东[1] 

机构地区：[1]广东省茂名市妇幼保健院检验科,广东茂名525000

出　　处：《中国医药指南》2012年第24期39-40,共2页Guide of China Medicine

摘　　要：目的探讨胱抑素C对(3～6)个月孕龄孕妇妊高征的预测价值。方法选取孕龄(3～6)个月的妊高征孕妇485例,以及同期同孕龄健康孕妇515例。收集其血清,测定血清胱抑素C、血尿素、血肌酐、尿酸以及肌酐清除率进行测定。结果观察组孕妇孕(3～6)个月时血清胱抑素C含量为(1.51±0.20)mg/L,明显高于对照组(0.81±0.12)mg/L的血清含量;晚期诊断为轻、中、重度妊高征孕妇在(3～6)个月孕龄时所查血清胱抑素C含量均高于正常妊娠组,且随着程度加重,含量明显升高。上述比较差异均具有显著性(P值均<0.05)。结论胱抑素C对妊娠高血压综合征的诊断和严重程度有着预测作用,其敏感性明显高于血清肌酐等内源性指标,应用中应结合临床进行综合评估,提高母婴生活质量。Objectives To observe the predictive value of cystatin C on pregnancy hypertension syndrome of 3-6 months. Methods 485 patients with pregnancy hypertension syndrome of 3-6 months and 515 healthy pregnant women of the same gestational age were selected. Collecting blood serum and determining the serum cystatin C, blood urea, serum creatinine, uric acid and creatinine clearance rate. Results The conmtent of serum cystatin C on pregnant women of 3-6 months in the observation group was （1.51±0.20） mg/L, which was higer significantly than the control group whose content of of serum cystatin C was （0.81 ±0.12 ） mg/L. The content of serum cystatin C on pregnancy hypertension syndrome of 3-6 months with late diagnosis of light, medium, heavy was higherthan the normal pregnancy group. And with the aggravation of degeree, the content increased significantly. The difference above had significance （P〈0.05）. Conclusions Cystatin C has prediction function on the diagnosis and severe degree of pregnancy hypertension syndrome. Its sensibility was higher significantly than serum creatinine and other endogenous index. We should combine the clinical to assess in application, to improve the life quality of maternal.

关 键 词：胱抑素C 妊高征 

分 类 号：R714.252[医药卫生—妇产科学]