脑心通联合阿托伐他汀对颈动脉粥样斑块干预的作用  

The intervention effect of Naoxintong combined with Atorvastatin on carotid atherosclerotic plaques

作　　者：纪宇鸿[1] 史海中[1] 王思露[1] 

机构地区：[1]河南省平舆县人民医院急诊科,河南平舆463400

出　　处：《中国民康医学》2012年第16期1923-1924,共2页Medical Journal of Chinese People’s Health

摘　　要：目的:观察脑心通联合阿托伐他汀对颈动脉粥样斑块干预的作用。方法:将130例门诊颈动脉粥样斑块患者随机分为三组。脑心通组(43例)在常规治疗基础上加服脑心通1.6g,3次/d;阿伐他汀组(43例)在常规治疗的基础上加口服阿伐他汀20mg,1次/晚;联合治疗组(44例)应用脑心通1.6g,3次/d,阿伐他汀20mg,1次/晚,均连用6个月。所有患者均于服药前和服药后6个月行颈动脉超声检查,观察各组患者用药前后颈动脉粥样斑块的变化,并进行比较。结果:三组患者用药前后自身对照,颈动脉粥样斑块明显减轻(P<0.05);用药前后单一用药组无明显差异(P>0.05);联合用药组较单一用药组明显减轻(P<0.05);各组均未见明显的不良反应。结论:脑心通和阿托伐他汀对颈动脉粥样斑块均有明显的抑制作用,两药联合效果更佳,且无明显不良反应。Objective：To observe the intervention effect of Naoxintong combined with atorvastatin on carotid atherosclerotic plaques.Methods： 130 patients with cervical atheromatous plaque were randomly divided into three groups.On the basis of conventional treatment,Naoxintong group（43 cases） were given Naoxintong 1.6g tid;Atorvastatin group（43 cases） were given Atorvastatin 20mg qn;The combination group（44 cases） were given Naoxintong 1.6g tid and Atorvastatin 20mg qn.All of them were given for 6 months.All patients were on medication before and after taking six months of carotid ultrasound,observed in all groups of patients before and after treatment of carotid atherosclerosis plaque changes,and compare.Results：Three groups of patients with medication carotid atherosclerotic plaque was significantly reduced（P〈0.05）;there were no significant differences before and after treatment in the single treatment group（P〉0.05）;however,the combined treatment group significantly reduced compared with the single treatment group（P〈0.05）;there was no obvious adverse reaction In each group.Conclusion：Naoxintong and atorvastatin on carotid artery atherosclerotic plaques has obvious inhibition,two medicine combined effect is better,and no obvious adverse reactions.

关 键 词：脑心通 阿托伐他汀 颈动脉斑块 

分 类 号：R543.5[医药卫生—心血管疾病]