微波辐射合成2-苯基-1H,1'H-2',5-双苯并咪唑  

Synthesis of 2-phenyl-1 H,1'H-2',5-bibenzo[d]imidazole with Microwave Radiation

作　　者：马柏林[1] 高娟丽[1] 闫宣凯[1] 杨鹏飞[1] 

机构地区：[1]西北农林科技大学理学院,陕西杨陵712100

出　　处：《西北林学院学报》2012年第5期135-138,共4页Journal of Northwest Forestry University

摘　　要：采用微波辅助,以3,4-二氨基苯甲酸和苯甲醛为原料,合成了2-苯基-1H,1'H-2',5-双苯并咪唑。探讨了物料比、微波输出功率、微波辐射时间和催化剂PPA与HCl比例对反应产率的影响。结果表明,第1步较佳反应条件为3,4-二氨基苯甲酸︰苯甲醛=1.0︰1.2,微波输出功率320W,间歇辐射30min;第2步较佳反应条件为5-(2-苯基-1H-苯并咪唑)甲酸︰邻苯二胺=1.0︰1.1,PPA/HCl=1︰1,微波输出功率500W,间歇辐射15min。该方法具有原料消耗少、操作简单、反应条件温和、易纯化、对环境无污染、产率高的优点。The synthesis of 2-phenyl-1H, 1＇H-2＇,5-bibenzo[d]imidazole under microwave irradiation by using 3,4-Diaminobenzoic acid and benzaldehyde as reactants was reported. The influences of the mole ratio of re- actants, output power of microwave generator, reaction time and the ratio of catalysts, which was PPA and HC1, on yield were investigated. At the first reaction, optimal reaction condition were obtained as the ratio of 3, 4-Diaminobenzoic acid to benzaldehyde was 1.0 ： 1.2, output power. 300 W, intermit radiate time： 30 minutes; at the second reaction, optimal reaction conditions were obtained as the ratio of 2-ben- zyl-1 H-benziminazole-5-methanoie acid to o-phenylenediamine was 1.0 ： 1.1, the ratio of PPA to HCl was 1 ： 1, output power= 500 W, intermit radiate time： 15 minutes. Compared to the previous methods, this new method has the advantages of simplified procedure, mild conditions, easy purification, and good yield.

关 键 词：2-苯基-1H 1'H-2' 5-双苯并咪唑 微波 合成 

分 类 号：Q621.392[生物学—生物物理学]