尿激酶动脉和静脉溶栓临床观察  

Urokinase arteries and veins thrombolysis clinical observation

作　　者：宋乐官 毕喜兵 

机构地区：[1]辽宁省东港市中医院,丹东118300

出　　处：《天津药学》2012年第4期42-43,共2页Tianjin Pharmacy

摘　　要：目的:比较尿激酶动脉溶栓和静脉溶栓的临床疗效,旨在探讨动脉溶栓的优点。方法:100例脑梗死患者随机分为动脉组50例和静脉组50例,动脉组采用尿激酶30～50万U加入氯化钠注射液30 ml颈动脉推注;静脉组用氯化钠注射液100 ml加尿激酶(100～150万U)在30 min内静脉滴注。两组患者均于12 h后复查凝血象和血小板,并给予低分子肝素钙4 100 U/次,2次/d皮下注射,24h后复查头CT,给予阿司匹林300 mg/次,1次/d口服,共3 d,3 d后改为100mg/d口服,同时常规给予静滴灯盏花和胞磷胆碱等药物治疗。结果:动脉组总有效率76%,静脉组总有效率60%,有显著性差异(P<0.05)。结论:尿激酶经颈动脉直接溶栓治疗急性脑梗死,疗效肯定,安全性好。Objective： To compare arterial thrombolysis and intraenous thrombolysis, aims to explore the chnieal curative effect of arterial thrombolysis advantages. Methods ： The selected 100 cases of cerebral infarction patients were rando mly divided into ar- tery and vein group, each group of 50 cases. Arterial group used the urokinase 30 - 50 million units ＋ 0.9% sodium chloride in- jection 30 ml to intravenous through the carotid , Vein group transfused 0.9% sodium chloride injection 100 ml add urokinase （ 100 - 150 million units）, completed in 30 minutes. After 12 hours, two groups of patients review out clotting time, platelets, and give the low molecular heparin calcium 4 100 units, subcutaneously twice. After 24 hours, review head CT, give aspirin 300mg day once oral, a total of three days, after three days instead 100 mg oral, at the same time, two groups are routinely offer static drops lamps flowers, cell diphosphate choline such drugs. Results： The artery group total effectiveness 76%, and venous group to- tal effectiveness 60%, a significant difference （P 〈 0.05）. Conclusion ： Urokinase by direct carotid thrombolytic treatment of a- cute cerebral infarction, high efficacy, safety.

关 键 词：尿激酶 颈动脉溶栓 急性脑梗死 

分 类 号：R973.2[医药卫生—药品]