VEGF、纤维蛋白原及D-二聚体在慢性硬膜下血肿中的作用及临床意义  

Role and clinical significance of VEGF,fibrinogen and D-dimer in chronic subdural hematoma

作　　者：华杰[1] 傅小君[1] 许信龙[1] 谢青松[1] 

机构地区：[1]浙江省慈溪市人民医院,慈溪315300

出　　处：《浙江创伤外科》2012年第4期433-435,共3页Zhejiang Journal of Traumatic Surgery

基　　金：浙江省慈溪市科技局资助项目(项目编号:CN2009017)

摘　　要：目的研究血管内皮生长因子(VEGF)、纤维蛋白原(Fibrinogen)及D-二聚体(D-dimer)与慢性硬膜下血肿(CSDH)发病机制及复发的关系。方法测定74例CSDH患者(包括7例术后复发病人)静脉血及血肿液中VEGF、纤维蛋白原及D-二聚体三种因子的含量,测定9例健康人静脉血中3种因子的含量作为对照。结果①CSDH患者血肿液中VEGF、D-二聚体的含量明显高于静脉血中的含量(P<0.05),而纤维蛋白原的含量明显低于静脉血中的含量(P<0.05);②CSDH术后复发患者血肿液中VEGF、D-二聚体的含量明显高于未复发患者(P<0.05),而复发患者纤维蛋白原的含量明显低于未复发患者(P<0.05);③CSDH患者静脉血中3种因子含量与健康人静脉血比较,差异无统计学意义(P>0.05)。结论 VEGF、Fibrinogen及D-dimer在CSDH的发病机制及复发中起重要作用。Objective To investigate the role of VEGF,fibrinogen and D-dimer in the pathogenesis and postoperative recurrence of chronic subdural hematoma（CSDH）.Methods To determine the content of VEGF,fibrinogen and D-dimer in the blood and hematoma fluid of 74 patients with CSDH（7 patients with recurrent hematoma）,and the content of these 3 factors in the blood of 9 healthy persons as control.Results ①The content of VEGF and D-dimer in the hematoma fluid were significantly higher than those in the blood of the CSDH patients（P〈0.05）,while the content of fibrinogen was significantly lower（P〈0.05）.②The content of VEGF and D-dimer in the recurrent hematoma were significantly higher than those in non-recurrent hematoma（P〈0.05） while the content of fibrinogen was significantly lower（P〈0.05）.③There were no significant differences in VEGF,fibrinogen and D-dimer contents in blood between the patients with CSDH and healthy persons（P〉0.05）.Conclusion VEGF,fibrinogen and D-dimer may play important roles in the pathogenesis and postoperative recurrence of CSDH.

关 键 词：慢性硬膜下血肿 血管内皮生长因子 纤维蛋白原 D-二聚体 

分 类 号：R651.15[医药卫生—外科学]