经鼻持续气道正压通气联合磷酸肌酸钠治疗新生儿重症肺炎合并心力衰竭的临床研究  

Clinical Research on Treatment of Neonates with Severe Pneumonia Complicated with Heart Failure by nCPAP and Creatine Phosphate Sodium

作　　者：肖吉群[1] 蔡苗[1] 

机构地区：[1]四川省宜宾市第二人民医院,四川宜宾644000

出　　处：《儿科药学杂志》2012年第9期23-25,共3页Journal of Pediatric Pharmacy

摘　　要：目的:探讨经鼻持续气道正压通气(nCPAP)联合磷酸肌酸钠治疗新生儿重症肺炎合并心力衰竭(心衰)的临床效果。方法:将74例重症肺炎合并心衰患儿采用抽签法随机分为治疗组46例与对照组28例。对照组给予头罩给氧、暖箱保暖、抗感染、强心、利尿等对症支持治疗及磷酸肌酸钠1 g/d静脉滴注,14 d一个疗程,治疗组在此基础上予nCPAP辅助治疗。结果:在气促消失、心率恢复正常、肝脏回缩、肺部啰音消失、动脉血气恢复正常、缩短平均住院日方面,治疗组均优于对照组(P<0.05或P<0.01)。治疗组显效率93.5%明显高于对照组60.7%(P<0.01);治疗组总有效率97.8%明显高于对照组71.4%(P<0.01)。结论:nCPAP联合磷酸肌酸钠为治疗新生儿重症肺炎合并心衰的有效方法,能迅速纠正低氧血症,改善心肺功能,减少对气管插管和机械通气的需求,避免呼吸机相关并发症的发生,降低病死率,值得临床推广。To study the compatibility of Reduning injection with common medicines.Methods： In accordance with the method described in China’s pharmacopoeia 2010 edition,the pH,insoluble particle,and the changes of spectral absorption after combination were assayed.Results： Reduning injection became dark,the spectral absorption curve changed,and chlorogenic acid decomposed which was a active substance when mixed with high pH injection such as injections containing sodium bicarbonate,amoxicillim/sulbactam sodium and dexamethasone sodium phosphate.Conclusions： Reduning injection should be diluted by 0.9% sodium chloride injection and applied intravenous infusion.Medicine combination of reduning injection and high pH medicines should be applied through separate injection or flushed perfusion tube.

关 键 词：经鼻持续气道正压通气 磷酸肌酸钠 重症肺炎 心力衰竭 新生儿 

分 类 号：R722.13[医药卫生—儿科]