nCPAP治疗阻塞性睡眠呼吸暂停低通气综合征合并心衰患者的临床观察  

Clinical observation of nasal continuous positive airway pressure treatment for obstructive sleep apnea hypopnea syndrome with chronic heart failure

作　　者：费静静[1] 华锋[1] 周玮[1] 陆晨[1] 

机构地区：[1]浙江省湖州市中心医院呼吸内科,浙江湖州313000

出　　处：《中国现代医生》2012年第25期134-135,138,共3页China Modern Doctor

基　　金：浙江省医药卫生科技计划项目(2011KYA153)

摘　　要：目的探讨经鼻面罩持续气道正压通气(nCPAP)治疗阻塞性睡眠呼吸暂停低通气综合征(OSAHS)合并慢性充血性心力衰竭(CHF)患者的临床疗效。方法选取OSAHS合并CHF患者96例,随机分为两组:实验组52例患者接受常规药物治疗的同时进行nCPAP治疗;对照组44例患者仅接受常规药物治疗。治疗6个月后观察治疗前后睡眠呼吸暂停低通气指数(AHI)、最低血氧饱和度(minSaO2)、左室舒张末期内径(LVDd)、左室射血分数(LVEF)及B型尿钠肽值(BNP)值的变化。结果实验组在常规药物联合nCPAP治疗6个月后,AHI、LVDd、BNP值较对照组明显下降,而最低SaO2、LVEF则明显升高(P<0.01)。结论 nCPAP治疗可消除呼吸暂停,纠正低氧血症,改善心力衰竭,对提高患者的治愈率和生活质量具有重要意义。Objective To observe the clinical effectiveness of nasal continuous positive airway pressure（nCPAP） treatment for obstructive sleep apnea hypopnea syndrome （OSAHS） combined with chronic heart failure （CHF）. Methods Ninety-six OSAHS combined with CHF patients were randomly divided into two groups： the experimental group was 52 cases accepted conventional treatments combined with nCPAP treatment; The control group was 44 cases only accepted conventional treatments. After treatment for 6 months, Apnea Hyponea lndex（AHI）,minimum blood oxygen saturation （minSaO2）,Left ventricular end-diastolic diameter （LVDd）,Left ventricular ejection fraction （LVEF） and B-type natriuretic peptide value （BNP） were observed. Results After 6 months treatment, the experimental group of AHI,LVDd, BNP value were significant lower than those of the control group;minSaO2 and LVEF increased significantly（P 〈 0.01 ）. Conclusion nCPAP treatment can eliminate apnea, correct hypoxia, improve heart failure and improve the cure rate and quality of life of patients.

关 键 词：阻塞性睡眠呼吸暂停低通气综合征 心力衰竭 正压通气 

分 类 号：R541.6[医药卫生—心血管疾病]