MSCT重组在组织工程骨修复颅骨缺损畸形中的应用  

The application of multislice CT and postprocessing technique in repairing cranial defects with tissue-engineered bone

作　　者：李春和[1] 李新庆[1] 王有刚[1] 崔磊[2] 刘广鹏[2] 

机构地区：[1]南京医科大学附属常州市第二人民医院放射科,江苏213003 [2]上海组织工程研究与开发中心,上海200241

出　　处：《放射学实践》2012年第9期994-997,共4页Radiologic Practice

基　　金：常州市卫生局重大科研课题(ZD200610);常州市科技局社会发展项目(CS2006201)

摘　　要：目的:探讨利用MSCT观察组织工程骨修复外伤后颅骨缺损畸形的生长情况。方法:9例颅骨缺损患者经组织工程骨的体外培养、构建后,进行手术回植到颅骨缺损区。分别于术前、术后1周和3、6、12个月进行MSCT及三维重组检查随访。结果:MSCT扫描及三维骨重组能清晰显示颅骨缺损及组织工程骨。术后1周MSCT均显示骨缺损区被所植入的组织工程骨填充,头颅外形明显改善。术后3～12个月CT显示组织工程骨形成并修复骨缺损,新生骨与骨缺损断端融合。结论:MSCT及其后处理重组可详细、直观地显示颅骨缺损及组织工程骨的生长情况。Objective：To evaluate the application of MSCT and postprocessing technique in repairing cranial defects caused by trauma with tissue-engineered bone.Methods：After proliferated and constructed in vitro,tissue engineered bones were used for implantation in 9 patients with skull defect.Gross observation and 3D-CT reconstruction were performed in preoperative 1 week and postoperative 1 week and 3,6,12 months.Results：In the nine cases,cranial defects and tissue-engineered bones were clearly shown on MSCT and 3D reconstructions.Postoperative 1 week MSCT scan showed the defect was filled with engineered bone,and the gross appearance of skull was obviously improved.After 3 and 12 months,new bone formed and fused with host bone,then the defects were repaired.Conclusion：MSCT scan and postprocessing techniques can produces stereoscopic images of cranial defects and growth of tissue-engineered bone.

关 键 词：组织工程 颅骨缺损 体层摄影术 X线计算机 

分 类 号：R651.1[医药卫生—外科学]