长期家庭氧疗对慢性阻塞性肺病的影响  

Effect of Long-term oxygen therapy on chronic obstructive pulmonary disease

作　　者：余维巍[1] 夏秦[1] 

机构地区：[1]华中科技大学同济医学院附属同济医院综合科,武汉430030

出　　处：《中国康复》2012年第4期280-281,共2页Chinese Journal of Rehabilitation

摘　　要：目的:观察长期家庭氧疗(LTOT)对慢性阻塞性肺病(COPD)患者气道壁厚度及肺功能的影响。方法:中重度COPD患者45例,随机分为家庭氧疗组(氧疗组)和对照组各20例,2组均接受常规药物治疗,氧疗组加用长期家庭氧疗。治疗前后行高分辨率螺旋CT(HRCT)扫描测试2组的气道壁厚度(WT)和气道壁相对面积值(WA%)及肺功能测试。结果:治疗2年后,对照组WT、WA%较治疗前明显增加(P<0.05),FEV1/FVC较治疗前明显降低(P<0.05),氧疗组各指标治疗前后比较差异无统计学意义。结论:长期家庭氧疗能有效改善COPD患者的气道重建及延缓患者的肺功能恶化。Objective： To explore the long-term oxygen therapy on bronchial wall thickness and lung function of chronic obstructive pulmonary disease. Methods：Forty patients with moderate-severe chronic obstructive pulmonary disease were randomly divided into LTOT group and control group. Both groups were given conventional rehabilita- tion, and LTOT group was given long-term oxygen therapy additionally. Pulmonary function test and HRCT scan were assessed. Results：After two years of treatment,the WT and WA% score of control group were increased than that of before（P〈0.05）. FEV1/FVC score of control group were lower than that of before（P〈0.05）. Every score of LTOT group were not significantly different from that of before. Conclusion：Long-term oxygen therapy could be effectively ameliorate the airway remodeling of patients with chronic obstructive pulmonary disease and reduce the degradation of lung function.

关 键 词：慢性阻塞性肺病 家庭氧疗 

分 类 号：R563.9[医药卫生—呼吸系统]