白细胞介素-28B基因多态性与丙型肝炎病毒感染自然清除的相关性  

Genetic polymorphisms of interleukin-28B are associated with spontaneous clearance of hepatitis C virusinfection

作　　者：谢俊强[1] 郭小燕[1] 李新华[1] 罗杰[1] 高志良[1] 赵志新[1] 

机构地区：[1]中山大学附属第三医院感染病科,广州510630

出　　处：《中华传染病杂志》2012年第9期538-541,共4页Chinese Journal of Infectious Diseases

基　　金：艾滋病和病毒性肝炎等重大传染病防治科技重大专项“十一五”计划资助项目（2008ZXl0002013）

摘　　要：目的探讨IL28B基因多态性与HCV感染自然清除的相关性。方法HCV感染者280例，其中慢性丙型肝炎患者200例，HCV感染后复查自发清除者80例，检测IL-28B基因rs8099917位点基因型，并分析IL-28B基因型与HCV感染自然清除的关系。统计学处理采用y。检验。结果慢性丙型肝炎组与自发清除组IL-28Brs8099917位点TT、非TT（TG和GG）基因型的频率差异有统计学意义（X^2=15．874，P〈O．01）。TT型在自发清除组中的频率为86．2％，高于慢性丙型肝炎组的62．0％。慢性丙型肝炎患者、自发清除者IL28Brs8099917T和G等位基因频率分别为78．0％、22．0％和92．5％、7．5％。自发清除人群中以T等位基因频率为主（92．5％），两组等位基因的差异有统计学意义（P〈O．01）。TT型HCV感染者自发清除HCV的可能性是非TT型感染者的2．84倍，而非TT型（TG＋GG）HCV感染者慢性化的危险性是TT型的1．36倍。结论宿主IL-28Brs8099917位点TT基因型与HCV感染自发清除相关，可作为HCV感染自发清除的一个重要预测因素。explore the association between interleukin （IL） 28B variation and spontaneous clearance of hepatitis C virus （HCV） infection. Methods A total of 280 HCV infected patients including 200 chronic hepatitis C （CHC） patients and 80 spontaneous clearance patients of HCV infection were enrolled in the study. The rs8099917 single nucleotide polymorphyism （SNP） of IL-28B gene was detected and the association between IL 28B variation and spontaneous clearance of HCV infection was analyzed. The data were compared using chi square test. Results The genotype frequencies of TT and non TT （TG and GG） of IL-28B rs8099917 between CHC patients and spontaneous clearance patients were not significantly different （Z2 = 15.874, P〈 0.01）. The prevalence of TT genotype in the spontaneous clearance group was 86. 2~, which was higher than that in CHC group （62.0~）. T and G allele frequencies in CHC group were 78. 0% and 22. 0% , respectively, and those in spontaneous clearance group were 92. 5% and 7.5% , respectively, which indicated that T allele was dominant in spontaneous clearance patients. The allele frequency of rs8099917 was statistically different Between the two groups （P〈0.01 ）. The spontaneous HCV clear rate in rs8099917 TT patients was 2.84 folds of non TT patients, while the risk of chronicity of non-TT （TG-kGG） patients was 1. 36 folds of TT patients. Conclusion The IL-28B （rs8099917） TT genotype is associated with spontaneous clearance of HCV infection, which can be an important factor to predict the spontaneous clearance of HCV.

关 键 词：肝炎 丙型 白细胞介素类 多态性 单核苷酸 基因型 等位基因 

分 类 号：R51[医药卫生—内科学]