纤维蛋白原是2型糖尿病尿蛋白进展的预测指标  

Fibrinogen is a predictor for progressive proteinuria in type 2 diabetes

作　　者：杨轶萍[1] 杨菊红[1] 常宝成[1] 单春艳[1] 郑妙艳[1] 王颖[1] 任惠珠[1] 陈莉明[1] 

机构地区：[1]天津医科大学代谢病医院糖尿病肾科、卫生部激素与发育重点实聆室,300070

出　　处：《中华内分泌代谢杂志》2012年第9期726-728,共3页Chinese Journal of Endocrinology and Metabolism

基　　金：围家自然科学基金项目（81072922,81173428）

摘　　要：回顾性分析2型糖尿病患者尿蛋白进展与凝血功能的关系。发现随着微量白蛋白尿的逐级增加，纤维蛋门原（FIB）明显增加，FIB是微量白蛋白尿升高的独立危险因素。且早期肾病进展至临床肾病组的基线FIB较非进展组升高[（3．5±0．9对3．0±0．6）g／L，P〈O．05]。FIB或可作为2型糖尿病尿蛋白进展的预测指标。The association of coagulation function with progressive proteinuria in type 2 diabetic patients wasretrospectively analyzed. With increasing microalbuminuria, fibrinogen level was increased significantly. Fibrinogen was an independent risk factor of microalbuminuria. In patients as the early-stage diabetic nephropathy （ DN ） progressed to clinical-stage DN, the baseline level of fibrinogen was also increased [ （ 3.5 ±0.9 vs 3.0±0. 6 ） g/L, P〈0.05 ]. Fibrinogen may serve as a useful predictor of progressive proteinuria in type 2 diabetes.

关 键 词：糖尿病 2型 糖尿病肾病 凝血 蛋白尿 纤维蛋白原 

分 类 号：R587.2[医药卫生—内分泌]