中药合剂抗运动病作用与对血液内分泌激素水平的影响  

Anti-motion sickness efficacy of the extracted mixture of Chinese Medical Herbs and its influence on the blood level of hormones

作　　者：沈华祥[1] 姜正林[1] 董根山[2] 杨红旗[2] 蒋锐[1] 李霞[1] 尹鹏[1] 陈苗苗[1] 

机构地区：[1]南通大学航海医学研究所,江苏南通226001 [2]河南省人民医院,郑州450003

出　　处：《中国应用生理学杂志》2012年第5期398-403,共6页Chinese Journal of Applied Physiology

基　　金：国家自然科学基金面上项目(81071614);江苏高校优势学科建设工程资助项目;南通大学自然科学基金交通运输专项(09ZJ005)

摘　　要：目的:研究酸枣仁等十味中药组成的合剂对运动病的作用及对血液内分泌激素水平的影响。方法:根据Cramptom和Lucot报道,以绕水平轴的旋转刺激SD大鼠与毕格犬,观察大鼠异食高岭土行为、犬呕吐潜伏期,采用绕垂直轴的旋转刺激豚鼠,记录眼震电图,观察中药合剂对这些指标的影响。同时,用放射免疫法测定大鼠血浆精氨酸加压素(AVP)、皮质酮(Cort)、促肾上腺皮质激素(ACTH)、促肾上腺皮质激素释放激素(CRH)水平,观察经口给予中药合剂对这些内分泌指标的影响。结果:与旋转刺激对照组比较,中药合剂:①抑制大鼠异食高岭土行为(P<0.05),延长犬呕吐潜伏期(P<0.05),该作用呈一定的剂量依赖性;②减少豚鼠眼震频率和平均慢相速度(P<0.05);③抑制大鼠血浆Cort、ACTH、CRH、AVP水平的升高;④中药合剂的这些作用与阳性对照药茶苯海明类似。结论:①本实验所用中药合剂能有效抑制运动病;②中药合剂可抑制旋转刺激引起的血浆下丘脑-垂体-肾上腺皮质轴激素和AVP水平的升高。Objective： To investigate the anti-motion sickness efficacy and influence on the blood level of some hormones of a Chinese prescription composed of 10 herbs such as spina date seed.Methods： According to the report by Cramptom and Lucot,SD rats and Beagle dogs were rotated around a horizontal axis,and the rat behavior of pica for Kaolin and the latency to vomit in dog were observed.In addition,guinea pigs were rotated around a vertical axis,and the nystagmus was recorded.Blood levels of corticosterone,adrenocorticotrophic hormone（ACTH）,corticotropin releasing hormone（CRH） and arginine vasopressin（AVP） in rats were measured with radioimmunoassay.The influences of the extracted mixture of herbs on these variables were simultaneously investigated.Results： Compared with control group,oral administration of the extracted mixture of herbs： ①significantly inhibited the rat behavior of pica for Kaolin and prolonged the latency to vomit in dog dose-dependently;②decreased the frequency of nystagmus and mean slow phase speed in rat;③reduced the elevation of corticosterone,ACTH,CRH and AVP in rat blood induced by rotatory stimulation;and ④these effects of the extracted mixture of herbs were almost identical to dimenhydrinate.Conclusion： ①The extracted mixture of Chinese Medicinal Herbs we used could inhibit motion sickness effectively.②This drug could reduce the blood levels of hormones of hypothalamic-pituitary-adrenocortical axis and AVP elevated by provocative rotatory stimulation.

关 键 词：大鼠 犬 豚鼠 中药 运动病 HPA轴 AVP 

分 类 号：R835.1[医药卫生—航空、航天与航海医学]