急性低氧性缺氧小鼠血液粘度与红细胞流变性变化  

Changes of blood viscosity and erythrocyte rheology in acute hypoxic hypoxia mices

作　　者：张敏[1] 李新妙[1] 冯季[1] 许帼杰[1] 刘晓彬[1] 姜华[1] 牛春雨[1] 赵自刚[1] 

机构地区：[1]河北北方学院微循环研究所,张家口075000

出　　处：《中国应用生理学杂志》2012年第5期454-457,共4页Chinese Journal of Applied Physiology

基　　金：河北省科技支撑计划(11276103D-84)

摘　　要：目的:观察小鼠急性低氧性缺氧(AHH)后红细胞流变性与血液粘度的变化。方法:32只健康昆明小鼠均分为:对照组、AHH组(复制模型,分为5 min、8 min、11 min三个亚组),在相应时间点,快速颈部脱臼后,从心尖取血,检测各组小鼠血液粘度与红细胞流变性指标。结果:与对照组相比,低氧5 min组各切变率下的全血粘度、全血相对粘度、全血还原粘度均显著降低,红细胞变形指数显著升高;低氧8 min组和低氧11 min组的群体细胞电泳时间显著延长、细胞电泳长度与细胞迁移率显著降低;低氧8 min组的全血相对粘度、全血还原粘度、红细胞聚集指数均显著高于、红细胞变形指数显著低于低氧5 min组。结论:AHH可引起小鼠血液粘度降低、红细胞电泳能力下降。Objective： To observe the changes of blood viscosity and erythrocyte rheology in mice after acute hypoxic hypoxia（AHH）.Methods： Thirty-two Kui-ming mice were radomly divided into control group,AHH group（duplicating AHH model,and divided into 5 min,8 min,11 min subgroups）,the blood sample was taken out from heart after neck dislocation at corresponding times,for detecting the blood viscosity and erythrocyte rheology indices.Results： Compared with control group,the whole blood viscosity at different shears,whole blood reduced viscosity,whole blood relative viscosity were lower and the erythrocytes aggregation index was higher in AHH 5 min group;the electrophoresis time was longer and the electrophoresis lengh,migration of erythrocyte were lower in AHH 8 min and AHH 11 min groups.The whole blood reduced viscosity,whole blood relative viscosity,erythrocytes aggregation index in AHH 8 min group were higher,and the erythrocyte deformability index was lower significantly than that of AHH 5 min group,respectively.Conclusion： These data suggested that the AHH could induce the blood viscosity and electrophoresis ablity.

关 键 词：低氧性缺氧 血液粘度 红细胞流变性 小鼠 

分 类 号：Q581[生物学—生物化学]