脑深部静脉和颈内静脉改变与多发性硬化的相关性研究  

Correlation of changes in cerebral deep vein and internal jugular vein with multiple sclerosis

作　　者：曾春[1] 李咏梅[1] 欧阳羽[1] 罗天友[1] 吕发金[1] 陈璇[1] 王忠平[1] 侯焕新[1] 

机构地区：[1]重庆医科大学附属第一医院放射科,重庆400016

出　　处：《第三军医大学学报》2012年第19期1994-1997,共4页Journal of Third Military Medical University

基　　金：国家自然科学基金(81171309);重庆市自然科学基金(CSTC2011JJA1073);重庆市卫生局重点课题(2011-1-031);重庆市卫生局课题(2010-2-004)~~

摘　　要：目的探讨脑内深部髓质静脉(deep medullary veins,DMVs)特征表现和颈内静脉(internal jugular veins,IJVs)改变与多发性硬化(multiple sclerosis,MS)的关系。方法对30例复发缓解型MS患者和30例年龄、性别匹配的非MS对照组行常规磁共振成像(magnetic resonance imaging,MRI)、三维增强T2*加权血管成像(3-dimensional enhanced T2*-weighted angiography,3-D ESWAN)和3-D时间分辨率对比剂动力成像(time-resolved imaging of contrast kinetics,TRICKs)扫描。观察患者和对照组侧脑室体旁DMVs在3-D ESWAN改变并评分;比较患者与对照组DMVs评分和IJVs狭窄发生率的差异,并评价DMVs和IJVs改变分别与EDSS评分和病程的相关性。结果①MS患者DMVs评分(1.67±0.25)较对照组(3.00±0.00)显著降低(P<0.01);16例病程>2.0年者为1分,8例病程0.5～2.0年者为2分,二者与对照组比较差异均有统计学意义(P<0.01),6例病程<0.5年者与对照组比较差异无显著性(P>0.05)。9个慢性病灶"穿通静脉"扩张和延长。②5例(16.7%)MS患者和2例(6.7%)对照组患者IJVs狭窄,2组IJVs狭窄发生率差异无统计学意义(P>0.05)。③IJVs狭窄与DMVs减少无显著相关性(P>0.05)。④DMVs减少、变短与患者病程呈显著负相关(r=-0.89,P<0.01),与EDSS评分无显著相关性(r=0.05,P>0.05);IJVs狭窄与EDSS评分和病程均无显著相关性(Z=0.20,P>0.05;Z=3.46,P<0.05)。结论 MS患者DMVs改变与IJVs狭窄无显著相关性。study the correlation of cerebral deep medullary vein （DMV） characteristics and changes in internal jugular vein （IJV） with multiple sclerosis （MS）. Methods Thirty recurrent remittent MS patients （MS group ） and 30 age- and sex-matched controls （control group ） underwent conventional magnetic resonance imaging （MRI）, 3-dimensional （3-D） enhanced T2 -weighted angiography （ ESWAN ）, and 3-D time-resolved imaging of contrast kinetics （TRICK）. Changes in periventricular DMV of MS group and control group were observed on 3-D ESWAN and scored. Results The periventricular DMV score was signifi- cantly lower in MS group than in control group （ 1.67±0.25 vs 3. O0±0.00, P 〈0.01 ）. The course of MS was 〉2.0 years in 16 patients with 1 score and 0.5±2.0 years in 8 patients with 2 scores （P〈0.01）, and 〈0.5 year in 6 patients （ P 〉 0.05 ）. Dilated and prolonged penetrating veins were found in 9 chronic MS lesions. IJV stenosis was observed in 5 （16.7%） MS patients and 2 （6.7%） controls, respectively （P 〉0. 05）. The IJV stenosis was not significantly correlated with the reduced DMV （P 〉 0.05 ）. The reduced and shortened DMV were positively correlated with the course of MS （ r = - 0.89, P 〈 0.01 ） but negatively correlated with the expanded disability status scale （EDSS） score （r = 0.05, P 〉 0.05 ）. The IJV stenosis was not significantly correlated with the EDSS score and the course of MS （Z = 0.20, P 〉 0.05 ; Z = 3.46, P 〈 0.05）. Conclusion Changes of periventrieular DMV are not significantly correlated with HV stenosis in MS natients.

关 键 词：多发性硬化 磁共振成像 脑深部静脉 颈内静脉 

分 类 号：R445.2[医药卫生—影像医学与核医学] R744.51[医药卫生—诊断学]