过敏性疾病家族史与儿童哮喘发病的相关研究  

Relationship between hereditary factors and asthma in children from Hefei city

作　　者：沈暐[1] 潘家华[1] 

机构地区：[1]安徽医科大学附属省立医院儿科,安徽合肥230001

出　　处：《安徽医药》2012年第9期1290-1291,共2页Anhui Medical and Pharmaceutical Journal

摘　　要：目的探讨儿童哮喘与过敏性疾病家族史之间的关系,从而了解遗传对儿童哮喘的影响。方法以2010年合肥市0～14岁儿童作为研究对象,通过整群抽样结果开展统一的问卷调查,并进行病例对照研究,结果行统计学分析。结果病例组中有家族过敏史者占24.67%,对照组中仅占4.79%,差异有统计学意义;一级亲属过敏性疾病患病率高于二级亲属(P<0.05);哮喘和其他过敏性疾病家族史对儿童哮喘都有显著影响,两者之间比较无统计学差异。结论过敏性疾病家族史与儿童哮喘发生有密切关系,诊断哮喘时应仔细询问家族史。Objective To investigate the relationship between family history of allergic diseases and childhood asthma, and to explore the impact of heredity. Methods Based on cluster-sampling method, a questionnaire survey ＇was conducted on 0 - 14 years old children in Hefei city. Case-control study and statistical analysis were performed to find the relationship between family history of allergic diseases and asthma. Results 24.67% of cases in the study group had family history of allergic diseases, while 4.79% of all in the control group had the same family history. Significant differences were observed between the two groups. The incidence rate of allergic diseases in the first-degree relatives was more than that in the second-degree relatives （P 〈 0. 05）. Family history of asthma and other allergic diseases had great influences on asthma in children. Conclusion The incidence of asthma in children is closely associated with genetic factors, Family history should be carefully asked about when children are diagnosed with asthma.

关 键 词：哮喘 过敏性疾病家族史 儿童 

分 类 号：R725.6[医药卫生—儿科]