糖尿病酮症酸中毒患者甲状腺激素水平的变化  

Changes of thyroid hormone in patients with diabetic ketoacidosis

作　　者：罗莉[1] 邓大同[1] 王长江[1] 

机构地区：[1]安徽医科大学第一附属医院内分泌科,安徽合肥230022

出　　处：《安徽医药》2012年第9期1317-1318,共2页Anhui Medical and Pharmaceutical Journal

基　　金：安徽省卫生厅自然科学基金(No09B104)

摘　　要：目的观察糖尿病酮症酸中毒患者甲状腺激素的变化,并探讨其意义。方法选择糖尿病酮症酸中毒患者38例(DKA组),无急性并发症的糖尿病患者36例(DM组),采用电化学发光法测定其甲状腺激素及促甲状腺激素(TSH)水平,同时检测糖化血红蛋白(HbA1c),比较两组血清甲状腺激素水平及糖化血红蛋白,并探讨T3、T4与HbA1c之间的相关性。结果与DM组相比,DKA组血清T3、T4水平明显降低(P<0.05),血清TSH无明显差异,HbA1c水平明显升高(P<0.05);Pearson分析在T3、T4与HbA1c间未发现明显相关性(P>0.05)。结论糖尿病患者在并发急性并发症时T3、T4水平下降,测定甲状腺激素水平有助于判断糖尿病患者的基本情况。Objective To compare the changes of serum thyroid hormones level in patients with diabetic ketoacidosis （DKA） and patients only with diabetes mellitus （DM） , in order to find out the clinical significance of the changes. Methods Inpatients with diabetic ketoacidosis （n = 38 ）and only with diabetes mellitus （n = 36 ） from Endocrinology Departments were randomly choose from 2010 to 2011. Their thyroid hormones and glycosylated hemoglobinA1 c （ HbA1 c） were assayed. The difference of thyroid hormone levels and glycosylated hemoglobinAlc in each group were analyzed. Results The serum levels of T3 ,T4 in Group DKA patients were significantly lower than those in Group DM patients （ P 〈 0.05 ） . However, the serum levels of TSH were not significantly different among the two groups （ P 〉 0.05 ）. Serum HbA1 c levels were not correlated with serum thyroid hormones levels （ P 〉 0.05 ）. Conclusion The serum thyroid hormones were much lower in DKA patients. Determination of these parameters might be of help for assessment of general condition of the patients.

关 键 词：糖尿病酮症酸中毒 甲状腺激素 糖化血红蛋白 

分 类 号：R587.2[医药卫生—内分泌]