纳米技术在药物制剂研究中的应用  

Application of Nanotechnology in the Development of Pharmaceutical Preparations

作　　者：高洁[1] 连潇嫣[2] 魏振平[3] 王博[2] 李洪起[2] 任晓文[2] 

机构地区：[1]天津中医药大学研究生院,天津300193 [2]天津药物研究院,天津300193 [3]天津大学化工学院,天津300072

出　　处：《化学工业与工程》2012年第5期64-69,共6页Chemical Industry and Engineering

基　　金：国家重点基础研究发展计划项目(2010CB735602);天津药物研究院(300193)

摘　　要：药物的水难溶性以及由此导致的低生物利用度是阻碍药学发展的主要原因之一,随着纳米技术的发展以及在药物制剂研究的应用,有些水难溶药物生物利用度低的问题已经得到了较好的解决。本论文在对纳米技术进行简介的基础上,重点介绍了该技术在微乳液、固体脂质纳米粒、纳米凝胶、聚合物纳米粒及纳米结晶等新型给药系统中的应用。在介绍纳米药物相对于传统药物的主要优势时,也对纳米技术在药物制剂研究中潜在的问题也进行了提示,以使纳米技术在新型药物制剂的研究中发挥更好作用。The lower bioavailability caused by poor water solubility is one of the important factors that hur- dled the development and reasonable use of the pharmaceutical APIs. However, with the application of the nanotechnology in the development of pharmaceutical preparations, the bioavailability for some of the poorly water-soluble drugs had been greatly improved. In this article, applications of nanotechnology were introduced in pharmaceutical preparations as dosage-forms of microemulsion, solid lipid nanoparticles, nanogel, polymeric nanoparticle and nanocrystals. The possible problems resulted from the use of nano- preparations were discussed together with their advantages over the traditional dosage-forms with the pur- pose of expanding the application of nanotechnology in the R＆D of novel pharmaceutical preparations.

关 键 词：纳米 纳米技术 药物制剂 

分 类 号：TQ46[化学工程—制药化工]