f-CTBN/PEG聚氨酯的合成及与血液相容性研究  

Study on Preparation of f-CTBN/PEG Polyurethanes and Performance of its Hemocompatibility

作　　者：张常虎[1] 

机构地区：[1]西安文理学院化学与化学工程学院,西安710065

出　　处：《工程塑料应用》2012年第10期15-20,共6页Engineering Plastics Application

基　　金：陕西省分析化学重点学科基金支助项目;西安文理学院中青年科研基金项目(kyc201014)

摘　　要：以功能化丁腈橡胶(f-CTBN)与不同的聚乙二醇(PEG)为原料,采用逐步聚合法得到一系列高支化嵌段聚氨酯(PUR)。通过材料亲水性测试、与健康人血的溶血实验和医学凝血实验研究了该PUR材料的血液相容性。结果表明,随f-CTBN含量的增大,该PUR材料的亲水性变差,不同固化剂对其亲水性影响不大;f-CTBN含量的增大只改变材料自身性质,而其溶血性、动态凝血时间及凝血酶原时间、部分凝血活酶时间和再钙化时间都在医学允许范围之内,说明其血液相容性好。该材料在介入诊疗和医用薄膜方面具有应用潜力。A series of hyperbranched block polyurethane （ PUR ） mareials were prepared on the basis of functional carboxyl- terminated poly （ butadiene-co-acrylonitrile ） （f-CTBN） and various poly （ ethylene glycol ） （ PEG ） by step-by-step polymerization. The hemocompatibility of bicomponent f-CTBN/PEG PUR materials was studied through the hydrophilicity, blood compatibility and coagulation experiment.The results showed that hydrophilicity of materials decreased with enhancing off-CTBN content, but different curing agents had little effect on material ＇ s hydrophilicity.The inhancement of component ratios off-CTBN to PEG had important influence on properties of material, but hemolytic activity, dynamic coagulation time and prothrombin time （ PT ）, partial thromboplastin time （ APTT ）, recalcification time （ PRT ） were completely in medical allowable range.So the PUR material＇ s hemocompatihility was good.The PUR materials would have application potentials in the intervention clinics and medical film products.

关 键 词：高支化聚氨酯 溶血性 凝血性 血液相容性 

分 类 号：TQ323.8[化学工程—合成树脂塑料工业]