Effects of vagus nerve preservation and vagotomy on peptide YY and body weight after subtotal gastrectomy  

作　　者：Hyung Hun Kim Moo In Park Sang Ho Lee Hyun Yong Hwang Sung Eun Kim Seun Ja Park Won Moon 

机构地区：[1]Departments of Internal Medicine,Kosin University College of Medicine,Busan 602-702,South Korea [2]Departments of Surgery,Kosin University College of Medicine,Busan 602-702,South Korea [3]Departments of Laboratory Medicine,Kosin University College of Medicine,Busan 602-702,South Korea

出　　处：《World Journal of Gastroenterology》2012年第30期4044-4050,共7页世界胃肠病学杂志（英文版）

摘　　要：AIM:To investigate the relationship between the function of vagus nerve and peptide YY 3-36 and ghrelin levels after subtotal gastrectomy.METHODS:We enrolled a total of 16 patients who underwent subtotal gastrectomy due to gastric cancer.All surgeries were performed by a single skilled surgeon.We measured peptide YY 3-36,ghrelin,leptin,insulin,growth hormone levels,and body weight immediately before and one month after surgery.RESULTS:Vagus nerve preservation group showed less body weight loss and less increase of peptide YY 3-36 compared with vagotomy group(-5.56 ± 2.24 kg vs-7.85 ± 1.57 kg,P = 0.037 and 0.06 ± 0.08 ng/mL vs 0.19 ± 0.12 ng/mL,P = 0.021,respectively).Moreover,patients with body weight loss of less than 10% exhibited reduced elevation of peptide YY 3-36 level,typically less than 20% [6(66.7%) vs 0(0.0%),P = 0.011,odd ratio = 3.333,95% confidence interval(1.293,8.591)].CONCLUSION:Vagus nerve preservation contributes to the maintenance of body weight after gastrectomy,and this phenomenon may be related to the suppressed activity of peptide YY 3-36.AIM：To investigate the relationship between the function of vagus nerve and peptide YY 3-36 and ghrelin levels after subtotal gastrectomy.METHODS：We enrolled a total of 16 patients who underwent subtotal gastrectomy due to gastric cancer.All surgeries were performed by a single skilled surgeon.We measured peptide YY 3-36,ghrelin,leptin,insulin,growth hormone levels,and body weight immediately before and one month after surgery.RESULTS：Vagus nerve preservation group showed less body weight loss and less increase of peptide YY 3-36 compared with vagotomy group（-5.56 ± 2.24 kg vs-7.85 ± 1.57 kg,P = 0.037 and 0.06 ± 0.08 ng/mL vs 0.19 ± 0.12 ng/mL,P = 0.021,respectively）.Moreover,patients with body weight loss of less than 10% exhibited reduced elevation of peptide YY 3-36 level,typically less than 20% [6（66.7%） vs 0（0.0%）,P = 0.011,odd ratio = 3.333,95% confidence interval（1.293,8.591）].CONCLUSION：Vagus nerve preservation contributes to the maintenance of body weight after gastrectomy,and this phenomenon may be related to the suppressed activity of peptide YY 3-36.

关 键 词：Peptide YY Ghrelin Vagotomy Gastrectomy Body weight 

分 类 号：R656.6[医药卫生—外科学]