姜黄素液晶纳米粒大鼠口服吸收的研究  

Study on the oral absorption of curcumin-loaded liquid crystalline nanoparticles in rats

作　　者：刘秀菊[1] 苏旬[2] 郭京艳[3] 贺秀丽 翟光喜[2] 

机构地区：[1]山东大学附属省立医院药剂科,山东济南250022 [2]山东大学药学院,山东济南250012 [3]山东省医科院附属医院药剂科,山东济南250031

出　　处：《中国医院药学杂志》2012年第18期1423-1426,共4页Chinese Journal of Hospital Pharmacy

基　　金：山东省科技攻关项目(编号:2010GWZ20203)

摘　　要：目的:研究姜黄素液晶纳米粒大鼠的口服吸收。方法:采用热处理-高压匀质法制备姜黄素液晶纳米粒,利用HPLC测定血浆中姜黄素浓度,DAS 2.0软件处理数据,求算药动学参数。结果:姜黄素液晶纳米粒口服吸收符合单室模型;与原料药组相比,姜黄素液晶纳米粒口服相对生物利用度为395.56%。结论:液晶纳米粒显著提高了姜黄素的口服吸收。OBJECTIVE To study the oral absorption of curcumin-loaded liquid crystalline nanoparticles in rats.METHODS Curcumin loaded liquid crystalline nanoparticles were prepared with the method of hot treatment and high-pressure homogenization,curcumin in plasma was determined by HPLC and the results were analyzed with Program DAS 2.0 to obtain the pharmacokinetics parameters.RESULTS The oral absorption of curcumin loaded liquid crystalline nanoparticles in rat fitted one-compartment model,and the relative bioavailability was 395.56% compared to crude CUR.CONCLUSION Liquid crystalline nanoparticles could markedly improve the oral absorption of CUR in rat.

关 键 词：姜黄素 纳米粒 生物利用度 

分 类 号：R285[医药卫生—中药学]