胎盘型钙黏蛋白在寻常性银屑病患者血清和皮损中的表达及意义  

Expression and significance of P-cad in patients with psoriasis vulgaris

作　　者：李高峰 袁皓琛 

机构地区：[1]江苏省扬州大学第二临床医院皮肤科,扬州225001

出　　处：《实用皮肤病学杂志》2012年第5期261-264,共4页Journal of Practical Dermatology

摘　　要：目的探讨胎盘型钙黏蛋白(P-cadherin,P-cad)在寻常性银屑病发病中的作用和意义。方法选择寻常性银屑病患者40例,分别采用酶联免疫吸附法和免疫组化法检测患者血清和皮损中P-cad的表达,另40名正常人作为对照。结果寻常性银屑病患者血清中P-cad表达水平明显高于正常对照者(P<0.01),表达水平与病情严重程度呈正相关;寻常性银屑病患者皮损中P-cad在角质形成细胞(keratinocyte,KC)各层均有表达,而正常对照组仅在表皮基底层表达,表达水平差异有统计学意义,且与银屑病皮损严重程度指数(PASI)呈正相关。结论 P-cad在寻常性银屑病呈高表达,且与疾病严重程度呈正相关。Objective To explore the role of P-cad in the pathogenesis of psoriasis vulgaris. Methods Venous blood was collected from 40 healthy control and 40 patients with psoriasis vulgaris. The serum P-cad was detected by ELISA. The expression of P-cad in skin lesion was analyzed by immunohistochemical staining. Results Expression level of P-cad in psoriasis vulgaris serums was significantly higher than in normal controls （P〈0.01）, expression level relates to severity of illness, which was a positive correlation. Expression strong of P-cad in skin lesions of psoriasis vulgaris while healthy control group was just expressed in basal layer of epidermis. Conclusion Expression level of P-cad in psoriasis vulgaris was significantly higher than in normal controls, expression level relates to severity of illness, which was a positive correlation.

关 键 词：银屑病 寻常性 钙黏蛋白 胎盘型 

分 类 号：R758.63[医药卫生—皮肤病学与性病学]