GC测定盐酸氟西汀中二氯甲烷残留量  

Determination of Residual Dichloromethan in Fluoxetine by GC

作　　者：刘秀英[1] 郑世君[1] 王玉梅[1] 陈建征[1] 张桂森[1] 

机构地区：[1]江苏恩华药业股份有限公司技术中心,江苏徐州221007

出　　处：《中国现代应用药学》2012年第9期849-851,共3页Chinese Journal of Modern Applied Pharmacy

摘　　要：目的采用气相色谱法检测盐酸氟西汀中的二氯甲烷残留量。方法色谱柱:DB-624毛细管柱(30 m×0.53 mm);载气:高纯氮气,0.05 MPa;检测器:ECD;进样口温度:150℃;检测器温度:300℃;柱温为程序升温;进样量:1μL;分流比:1∶20。结果二氯甲烷在5.96～71.55μg.mL 1内,峰面积和浓度之间呈良好的线性关系(r=0.999 6),3批样品中的二氯甲烷残留量均符合规定(<0.06%)。结论该方法操作简便,精密度好,准确性高,可用于检测盐酸氟西汀中二氯甲烷残留量。OBJECTIVE To detect the residue dichloromethane in fluoxetine by gas chromatography（GC）.METHODS Residue dichloromethane in fluoxetine was detected by GC with DB-624 column（30 m×0.53 mm）,ECD detector and nitrogen as carrier gas（0.05 MPa）.Injector and detector temperatures was set at 150 and 300 ℃ respectively.Column temperature was programmed set.Injection volume was 1 μL and the split ratio was 1 ∶ 20.RESULTS Dichloromethane showed a good linear relationship in the range of 5.96~71.55 μg.mL 1（r=0.999 6）,the residue dichloromethane in three batches of samples coincided with the requirements（0.06%）.CONCLUSION Gas chromatography（GC） is simple,accurate,sensitive.It can be used for the determination of dichloromethane in fluoxetine.

关 键 词：气相色谱法 盐酸氟西汀 二氯甲烷 

分 类 号：R284.1[医药卫生—中药学] R917.101[医药卫生—中医学]