石墨烯修饰玻碳电极伏安法测定美洛昔康  

Voltammetric determination of meloxicam at a graphene modified glassy carbon electrode

作　　者：习霞[1] 明亮[1] 

机构地区：[1]南通大学化学化工学院,南通226007

出　　处：《分析试验室》2012年第10期92-95,共4页Chinese Journal of Analysis Laboratory

基　　金：南通大学自然科学项目(10Z015);南通市应用研究科技计划项目(K2006018)资助

摘　　要：通过在玻碳电极表面电化学还原氧化石墨烯的方法制备了石墨烯修饰电极,研究了美洛昔康在该修饰电极上的电化学行为。优化了包括支持电解质及pH、修饰剂用量、富集电位及时间等测定条件,据此建立了一种直接测定美洛昔康的电化学分析方法。在0.1 mol/L Britton-Robinson缓冲液(pH 3.0)中,氧化峰电流与美洛昔康浓度在1.0×10-6～8.0×10-5mol/L范围内呈现良好的线性关系,检出限为3.0×10-7mol/L(S/N=3)。方法可用于片剂和尿样中美洛昔康的测定。A graphene modified electrode was prepared through electrochemical reduction of graphene oxide （GO） on the surface of a glassy carbon electrode （GCE） and the electrochemical behavior of meloxicam （MLX） at this modified glassy carbon electrode was investigated. The experimental parameters such as the supporting electrolyte and buffer pH, the amount of GO suspension, the accumulation potential and time were optimized, and a direct eleetroanalytical method for the determination of meloxicam was developed. The oxidation peak current was proportional to the concentration of meloxicam in the range of 1.0 × 10-6 - 8.0 × 10-5 mol/L with a detection limit of 3.0 × 10-7 mol/L （SIN = 3） in 0. 1 mol/L proposed method was used for the determination of meloxicam Britton-Robinson buffer solution （pH 3.0）. The in tablets and human urines.

关 键 词：美洛昔康 石墨烯 伏安法 化学修饰电极 

分 类 号：O657.1[理学—分析化学]