^131碘治疗后亚临床甲状腺功能亢进患者血清骨钙蛋白与促甲状腺素水平变化  

Levels of serum bone gla protein and thyroid-stimulating hormone in patients with subclinical hyperthyroidism after 131iodine therapy

作　　者：张海三[1] 张红星[2] 刘保平[1] 

机构地区：[1]郑州大学第一附属医院核医学科,450000 [2]新乡医学院第二附属医院,453002

出　　处：《实用医学杂志》2012年第19期3213-3215,共3页The Journal of Practical Medicine

基　　金：河南省重点科技攻关项目(编号:092102310273)

摘　　要：目的:了解131碘治疗后亚临床甲状腺功能亢进患者血清骨钙蛋白(BGP)水平变化及其与血清促甲状腺激素(TSH)的关联。方法:279例患者131碘治疗后随访1年,应用放射免疫分析法于随访6个月(6m)、12个月(12m)时测定血清甲状腺相关激素水平(FT3、FT4、TSH)和血清BGP,根据血清甲状腺相关激素水平分为亚临床甲状腺功能亢进组(亚甲组,73例)、康复组(206例),另选择132例相匹配的志愿者为健康对照组(对照组),SPSS13.0软件分析不同时间3组间血清BGP、TSH水平差异及二者相关性。结果:3组间6个月与12个月时血清BGP水平均有统计学差异(F6m=852.71,P6m=0.000;F12m=1053.56,P12m=0.000);两两比较,差异均有显著性(P<0.001),亚甲组血清BGP高于其他两组;病例组血清BGP与血清TSH相关系数r=-0.568,P=0.000。结论:131碘治疗后亚临床甲亢患者血清BGP水平异常增高,其升高可能与低TSH相关。Objective To analyze the levels of serum bone gla protein （BGP） and thyroid-stimulating hormone （TSH） and observe the relationship of them from the patients with subclinical hyperthyroidism after 131iodine therapy. Methods BGP and TSH were detected by using radio immunoassay in 73 patients with subclinical hyperthyroidism, 206 cases recovered hyperthyreosis patients after 131iodine therapy and 132 cases as health controls. SPSS soft was used to analyze the difference of the levels of BGP among the three groups and the correlation between serum BGP and TSH. Results There were significant differences of serum BGP among the three groups at the end of 6 moths and 12 moths （F6m= 852.71 ,P6m = 0.000;F12m = 1 053.56,P12m. = 0.000）. And there was significant difference between any two groups, and it was the highest in subclinical hyperthyroidism group. In two patients groups, there was positive correlation between BGP and TSH （r = -0.568,P = 0.000）. Conclusion BGP increased in patients with subclinical hyperthyroidism after 131iodine therapy, which is related to the low TSH level.

关 键 词：甲状腺功能亢进症 亚临床 骨钙素 促甲状腺激素 

分 类 号：R581.1[医药卫生—内分泌]