3种亲水性聚合物对酮洛芬/环糊精包合物增溶作用的影响  

Effects of 3 Kinds of Hydrophilic Polymers on Ketoprofen/Cyclodextrin Complex Solubilization

作　　者：许伟[1] 

机构地区：[1]辽宁省肿瘤医院药剂科,沈阳110042

出　　处：《中国药房》2012年第37期3491-3492,共2页China Pharmacy

摘　　要：目的:研究聚合物对酮洛芬/环糊精包合物中药物溶解度的影响。方法:在酮洛芬/羟丙-β-环糊精体系中不加聚合物以及分别添加浓度均为0.1%的聚乙烯吡咯烷酮(K30)、羟丙基甲基纤维素(HPMC)、聚乙二醇(6000)3种高分子水溶性聚合物的情况下,于25℃下采用相溶解度法,考察药物在4种体系中的溶解度和表观稳定常数(Ks)。结果:4种体系中,以加入聚乙二醇(6000)后酮洛芬的溶解度增加最明显,从172.9mmol·L-1增加到308.9mmol·L-1,Ks从0.042增大到0.940。结论:亲水性聚合物聚乙二醇(6000)能够增强药物与环糊精的包合作用。OBJECTIVE： To investigate the effect of hydrophilic polymers on the solubility of drug in ketoprofen/cyclodextrin complex. METHODS： Different kinds of polymers including 0.1% PVP K30, 0.1% HPMC, 0.1% PEG 6000, were added into the ketoprofen/cyclodextrin system respectively or not, and phase solubility method was adapted to calculate the dissolution and the ap- parent stability constants （Ks） under 25 ℃. RESULTS： In 4 kinds of system, PEG 6000 increased the solubility of ketoprofen sig- nificantly, which was from 172.9 mmol. L i to 308.9 mmol.L 1, and the K,increased from 0.042 to 0.940. CONCLUSION： Hydro- philic polymer PEG 6000 is shown to increase the clathration effect of cyclodextrin on drugs.

关 键 词：环糊精包合物 酮洛芬 聚乙烯吡咯烷酮 羟丙基甲基纤维素 聚乙二醇 增溶作用 溶解度 表观稳定常数 

分 类 号：R943[医药卫生—药剂学]