宾川獐牙菜中苷类成分研究  

Glycosides Constituents of Swertia binchuanensis

作　　者：李兆云[1] 康绍龙[1] 李冬梅[1] 施贵荣[1] 肖怀[1] 

机构地区：[1]大理学院.药学与化学学院,云南大理671000

出　　处：《时珍国医国药》2012年第9期2162-2163,共2页Lishizhen Medicine and Materia Medica Research

基　　金：云南省自然科学基金(No.2009ZC122M);云南省教育厅重点项目(No.09Z0079)

摘　　要：目的研究宾川獐牙菜(Swertia binchuanensis)的化学成分,寻找生物活性物质。方法用系统溶剂提取,常规硅胶柱色谱和薄层色谱进行分离纯化,根据化合物的物理、化学性质,UV、IR、MS、1H-NMR、13C-NMR等波谱鉴定其结构。结果从宾川獐牙菜中分离得到4个化合物,分别鉴定为1-O-[β-D-吡喃木糖-(1-6)-β-D-吡喃葡萄糖]-3,5-二甲氧基酮(1-O-[β-D-xylopyranose-(1-6)-β-D-glucopyranose]-3,5-dimethoxyxanthone,I),8-O-β-D-吡喃葡萄糖-1,5-二羟基-3-甲氧基口山酮(swertianolin,II),β-胡萝卜苷(β-daucosterol,Ⅲ),β-谷甾醇(β-sitosterol,Ⅳ)。结论 4个化合物皆为首次从宾川獐牙菜中分离得到。Objective To study the glycosides constituents of Swertia binchuanensis for finding active compounds.Methods The constituents were separated and purified by column chromatography with silica gell.Their structures were identified on the basis of spectral analysis such as UV,IR,MS,1H-NMR,13C-NMR.Results Four compounds were isolated and identified as 1-O-[β-D-xylopyranose-（1-6）-β-D-glucopyranose]-3,5-dimethoxyxanthone（Ⅰ）,swertianolin（Ⅱ）,β-daucosterol（Ⅲ）,β-sitosterol（Ⅳ）.Conclusion All compounds were isolated from Swertia binchuanensis for the first time.

关 键 词：宾川獐芽菜 化学成分 酮 甾体 

分 类 号：R284.2[医药卫生—中药学]