沉降法制备新型聚氨酯血液相容性材料  

Preparation of New Blood Compatible Polyurethane Materials with Sedimentation

作　　者：何承爱[1] 邱化廷[1] 邵晓林[1] 魏云峰[1] 章峻[1] 

机构地区：[1]南京师范大学江苏生物功能材料重点实验室,南京210097

出　　处：《功能高分子学报》2012年第3期310-314,共5页Journal of Functional Polymers

基　　金：国家自然科学基金(20874047);江苏省自然科学基金(08KJB150010)

摘　　要：采用一种新型聚氨酯纳米微球(PUI-NPs)修饰聚氨酯(PU)薄膜,利用沉降法制备出具有良好血液相容性的聚氨酯/聚氨酯纳米微球(PU/PUI-NPs)。以扫描电镜、红外光谱、X射线光电子能谱对PU/PUI-NPs膜表面结构进行表征。以血小板黏附、复钙、溶血和蛋白吸附实验对PU/PUI-NPs膜的血液相容性进行了表征。结果表明:PUI-NPs已被成功引入PU膜表面,PU/PUI-NPs膜的血液相容性比PU有显著的提高,相比于PU,PU/PUI-NPs膜的细胞毒性更低。A kind of novel polyurethane ionomer nanoparticles（PUI-NPs） were used to modify polyurethane（PU） films.An excellent blood compatible polyurethane/polyurethane ionomer nanoparticles composite film（PU/PUI-NPs film） was prepared with sedimentation.The structure of the PU/PUI-NPs film was characterized with SEM,ATR-FTIR and XPS.Platelet adhesion,recalification time,hemolysis and protein adsorption measurement were used to assess the blood compatibility of PU/PUI-NPs film.Results showed that PUI-NPs was introduced into the PU surface successfully.The blood compatibility of PU/PUI-NPs film was improved remarkably,compared with that of PU.PU/PUI-NPs film had lower cytotoxicity than PU.

关 键 词：聚氨酯纳米微球 聚氨酯 表面改性 血液相容性 

分 类 号：O63[理学—高分子化学]