深在性红斑狼疮1例  

A Case of Lupus Erythematosus Profundus

作　　者：孙健[1] 崔丹[2] 

机构地区：[1]辽宁医学院附属第一医院皮肤性病科,辽宁锦州121001 [2]辽宁医学院附属第一医院病理科,辽宁锦州121001

出　　处：《中国皮肤性病学杂志》2012年第10期935-937,共3页The Chinese Journal of Dermatovenereology

摘　　要：患者女,37岁。右上臂斑块1年。皮肤科情况:右上臂前侧和后侧各见约1.5×2.5cm,1.5×4.0cm大小的淡红色浸润性斑块,表皮萎缩,质地较硬,活动度差,无压痛。皮损组织病理示:角化过度,表皮萎缩,基底细胞空泡化变性,真皮及皮下脂肪组织小血管扩张充血,小血管周围伴大量灶状淋巴细胞浸润,皮下脂肪小叶内大量淋巴细胞浸润。直接免疫荧光(LBT):表皮基底膜带C3,IgM呈线状沉积。诊断:深在性红斑狼疮。硫酸羟氯喹0.2g口服,2次/d,白芍总苷0.6g口服,3次/d,卤米松软膏、多磺酸黏多糖软膏外用。3周后皮损变软,面积变小。A 37 years female have plaques on right upper arm for 1 year. Physical examination found that infiltrated salmon pink plaques of 1.5cm x 2.5cm, 1.5 cm ×4.0cm were located in the front side and back side of right upper arm respectively. Epidermal atrophy, hard texture, poor activity, without tenderness. Histopathological examination of skin showed hyperkeratosis, epidermal atrophy, liquefaction degeneration of basal cells, small blood vessels dilation and congestion of dermal and subcutaneous adipose tissue, a large number of focal lymphocytic infiltration around the small vessel and the subcutaneous fat. Direct immunofluorescence （LBT） showed continuous linear deposits of C3 and IgM in epidermal basement membrane zone. The case was diagnosed as“lupus erythematosus profundus”. We gave the treatment of Hydroxychloroquine sulfate oral 0.2g, two times a day, and total glucosides of Paeony oral 0.6g, three times a day, Halometasone Cream and Sulfonic acid mucopolysaccharide ointment for external use. After 3 weeks, the skin lesions become soft, smaller area.

关 键 词：深在性红斑狼疮 硫酸羟氯喹 白芍总苷 卤米松软膏 多磺酸黏多糖软膏 

分 类 号：R593.24[医药卫生—内科学]