动态血压监测评价尼群洛尔片治疗原发性高血压的疗效  

Effect of nitrendipine and atenolol tablets on blood pressure in patients with hypertension assessed by ambulatory blood pressure monitoring

作　　者：孔玮[1] 贾乐陶[1] 钱岳晟[2] 吴宗贵[3] 俞新君[4] 魏福荣[4] 

机构地区：[1]江苏省镇江市第一人民医院,江苏镇江212001 [2]上海市高血压研究所,上海200025 [3]上海长征医院,上海200003 [4]江苏吉贝尔药业有限公司,江苏镇江212009

出　　处：《现代中西医结合杂志》2012年第29期3205-3206,3209,共3页Modern Journal of Integrated Traditional Chinese and Western Medicine

摘　　要：目的应用动态血压监测(ABPM)方法评价尼群洛尔片治疗原发性高血压的疗效。方法 22例原发性高血压患者经2周洗脱期,服用尼群洛尔片(尼群地平5 mg和阿替洛尔10 mg)2片/次,1次/d,4周末坐位舒张压(DBP)≥90 mmHg(1 mmHg=0.133 kPa)者加服1次。于洗脱期末及治疗8周末仍服药1次患者各行ABPM和实验室检查1次。结果ABPM显示8周末24 h平均血压、日间平均血压、夜间平均血压、白昼平均收缩压(SBP)负荷、夜间平均DBP负荷均比治疗前明显降低。降低SBP和DBP谷峰比分别为0.51和0.60;SBP和DBP的平滑指数分别为1.63和2.08,不良反应发生率低。结论尼群洛尔片每天服药1次治疗原发性高血压安全有效。Objective It is to assess the antihypertensive effects of nitrendipine and atenolol tablets on essential hypertension by ambulatory blood pressure monitoring(ABPM).Methods After 2 weeks' washout,22 patients with mild-to-moderate essential hypertension were treated with nitrendipine and atenolol tablets(nitrendipine 5 mg and atenolol 10 mg)2 pills qd.After 4 weeks' treatment,dosage was increased to 2 pills bid in patients when DBP≥90mmHg.Both ambulatory blood pressure monitoring(ABPM) and laboratory test were performed after washout time and at the end of 8 weeks treatment.Results There were significant differences in the reduction of 24 h,day-time,night-time average SBP or DBP,day-time systolic blood pressure load and night-time diastolic blood pressure load.The T/P ratio in SBP and DBP were 0.51 and 0.60 respectively.The smoothness index of SBP and DBP were 1.63 and 2.08 separately.The incidences of adverse effects were very low.Conclusion Nitrendipine and atenolol tablets used one time a day is effective and safe for essential hypertension.

关 键 词：尼群洛尔 原发性高血压 动态血压监测 

分 类 号：R544.1[医药卫生—心血管疾病]