广东省1型糖尿病患者发病风险与出生月份的相关性  

The correlation between the birth month and the risk of type 1 diabetes in Guangdong Province

作　　者：石一鸣[1] 严晋华[1] 杨黛稚[1] 邓洪容[1] 李津[1] 翁建平[1] 

机构地区：[1]中山大学附属第三医院内分泌与代谢病学科,广州510630

出　　处：《广东医学》2012年第18期2715-2717,共3页Guangdong Medical Journal

基　　金：广东省科技计划项目(编号:2010B031500008);中山大学临床医学研究5010计划资助项目(编号:2007030)

摘　　要：目的调查1型糖尿病发病风险是否与出生月份相关。方法调查在广东省全部21个地级市的105家三级和二级医院就诊的1型糖尿病患者,记录其出生日期、性别等人口学及病情资料。采用核平滑法计算不同出生月份的预期发病人数,并分析出生月份与1型糖尿病发病是否相关。结果共纳入2 227例1型糖尿病患者,在6—10月出生的患者较多,而在12月至4月出生的患者较少。其中以8月份出生的患者最多,1月份出生的患者最少(RR=1.26,P<0.01)。结论广东省1型糖尿病患者发病与出生月份可能相关,8月份出生者可能最易患1型糖尿病。Objective To investigate the correlation between the birth month and the risk of type 1 diabetes among people in Guangdong Province. Methods The birth month data, demographic information, and medical history of type 1 diabetic patients （medical records documented from January 2000 to March 2011 ） in 105 hospitals from all 21 cit- ies in Guangdong Province were collected. Kernel smoother technique was conducted to calculate expected incident number in each birth month. Results A total of 2 227 type 1 diabetic patients were included. After data smoothing, a deficit be- tween December and April, and an excess between June and October were revealed, among which the highest risk was Au- gust birth and the lowest risk was January birth （RR = 1.26, P 〈0. 01 ）. Conclusion August birth might be associated with risk of type 1 diabetes in Guangdong.

关 键 词：糖尿病 1型 广东省 出生月份 

分 类 号：R587.1[医药卫生—内分泌]