盐酸坦洛新缓释制剂的制备及体外释放度考察  

Preparation and in Vitro Release of Tamsulosin Hydrochloride Sustained-release Tablets

作　　者：范俊红 张二强 

机构地区：[1]四川成都林业中心医院药剂科,四川成都610081 [2]成都空军司令部机关医院院办,四川成都610041

出　　处：《中国医药指南》2012年第25期46-48,共3页Guide of China Medicine

摘　　要：目的研究坦洛新缓释片的处方、工艺,对其释放度进行考察。方法选用羟丙甲基纤维素(HPMC)为亲水凝胶型骨架材料,湿法制粒制备盐酸坦洛新缓释片,并采用正交实验设计优化处方;小杯桨法测定其释放度。结果优化处方组成为羟丙甲基纤维素(15M)占处方量的40%,羟丙甲基纤维素/甲基纤维素为5∶1,淀粉/乳糖为2∶1,乙基纤维素的用量为2mg/pcs;优化处方的缓释片体外释放曲线符合一级动力学程,释放度符合设计要求。结论本研究所制得盐酸坦洛新骨架缓释片具有良好的缓释效果,制备工艺合理,简单易行,可以满足盐酸坦洛新的临床需要。Objective To study the optimum preparation conditions of tamsulosin hydrochloride sustained-release tablets.Methods To prepare tamsulosin hydrochloride sustained-release tablets with hydrophilic gel matrix such as HPMC.Use wet granulation method to preparare the sustained-release tablets.Orthogonal design was used to evaluate drug release in vitro.Results According to results,the optimum preparation is A2B1C3D3.Conclusion The research provided an optimal method for the preparation of tamsulosin hydrochloride sustained-release tablets

关 键 词：盐酸坦洛新 缓释 体外释放 

分 类 号：R94[医药卫生—药剂学]