肝达康对DMN致肝损伤大鼠血清透明质酸、Ⅲ型前胶原、层粘连蛋白及肝组织羟脯氨酸水平的影响  

Effects of GDK on HA,PCШ,LN in Serum of Hepatic Injury Rats Induced by DMN and Its Influence on Content of Hydroxyproline

作　　者：柳成刚[1] 王晓丽[1] 姜德友[1] 张硕辛[1] 耿乃志[1] 解颖[1] 乔羽[1] 常佳怡[1] 

机构地区：[1]黑龙江中医药大学,黑龙江哈尔滨150040

出　　处：《中医药学报》2012年第4期36-38,共3页Acta Chinese Medicine and Pharmacology

基　　金：黑龙江省自然科学基金项目(D201037);黑龙江省中医药管理局项目(ZHY10-Z4);黑龙江省博士后基金资助课题(LBH-Z09010);黑龙江中医药大学科研基金资助(200909)

摘　　要：目的:观察肝达康对肝损伤大鼠血清透明质酸、Ⅲ型前胶原、层粘连蛋白及肝组织羟脯氨酸水平的影响。方法:55只Wistar大鼠,除空白对照组10只外,其余45只用1%DMN腹腔注射建立肝损伤大鼠模型,并同时分别给予药物或生理盐水灌胃,于第4周末处死全部大鼠,留取血清。观察肝达康对DMN肝损伤模型大鼠血清HA、PCⅢ、LN和肝组织Hyp含量的影响。结果:与正常对照组比,肝损伤模型组大鼠血清HA、PCⅢ、LN和肝组织Hyp含量均明显升高。经肝达康治疗后,上述指标的含量均明显降低。结论:肝达康能降低DMN致肝损伤模型大鼠血清透明质酸、Ш型前胶原、层粘连蛋白及肝组织羟脯氨酸水平。Objective ：To study the influence of GDK on Contents of HA, PCIII, LN and HYP in hepatic injury rats in- duced by DMN. Methods ： Fifty - five Wistar rats excluding ten rats in blank control group, and the other rats were injec- ted DMN to establish hepatic injury model rats. At the same time, all rats were given drugs or distilled water. Blood sam- ples were obtained at the end of the 4th week. The contents of HA, PCIII, LN in serum and HYP in liver were deter- mined. Results：Contents of HA, PCIII, LN in serum and HYP in liver of model rats were increased markedly as com- pared with the blank group. After the therapy of GDK, contents of HA, PCIII, LN and HYP in GDK group decreased. Conclusion ： GDK can decrease the contents of HA, PCIII, LN in serum and HYP in liver of hepatic injury rats Induced by DMN.

关 键 词：肝达康 肝损伤 透明质酸 Ⅲ型前胶原 层粘连蛋白 羟脯氨酸 

分 类 号：R285.5[医药卫生—中药学]