血液平衡疗法对原发性高血压的治疗作用及机制探讨  

Investigation of the effect and mechanism of the blood balance therapy on essential hypertension

作　　者：王保生[1] 王立赞[1] 王友[1] 王建礼[1] 王保平[2] 

机构地区：[1]济宁医学院基础学院,山东济宁272067 [2]济宁医学院血液稀释研究所

出　　处：《济宁医学院学报》2012年第4期262-264,共3页Journal of Jining Medical University

摘　　要：目的研究血液平衡疗法对原发性高血压的治疗作用,并通过观察血液流变学的变化探讨其作用机制。方法按WHO高血压诊断标准,确诊为原发性高血压患者45例,经肘静脉抽血至总血容量的8%～10%,同时等容输入稀释液;取抽出血液的1/4经低能量He-Ne激光紫外线复合照射、磁化充氧后回输。每周1次,4周为1疗程。治疗前及治疗1个疗程后测定动脉血压并肘静脉取血测定血液流变学指标。结果原发性高血压患者经1个疗程治疗后,动脉收缩压由(172±21)mmHg降至(135±17)mmHg(P<0.01),动脉舒张压由(112±13)mmHg降至(88±11)mmHg(P<0.01);全血黏度、血浆黏度和全血还原黏度均显著降低(P<0.01),红细胞压积和红细胞聚集指数明显降低(P<0.01),红细胞变形能力升高(P<0.01),血小板1min、5min和最大聚集率均有显著性降低(P<0.01)。结论血液平衡疗法能显著改善原发性高血压患者的血液流变学,具有较好的降压作用。Objective To investigate the effect of blood balance therapy on essential hypertension and the action mechanism by observing change of hemorrheology.Methods 45 cases of patients with essential hypertension were diagnosed according to diagnostic criteria of hypertension of WHO.The blood of patients was exsanguinated until 8 to 10 percent of blood volume via intermedian cubital vein,and the equivalent diluent was infused.A quarter of the bleeding blood by He-Ne laser ultraviolet irradiationmagnetization and oxygenate were reinfused once a week,and each treatment period was four weeks.Blood samples were taken from the intermedian cubital vein before treatment and after a period of treatment.The hemorrheolgical parameters were determined.Results After a period of treatment,the patients’ arterial blood pressure were decreased obviously（systolic pressure from 182±21 to 145±17（P〈0.01）,diastolic pressure from 112±13 to 88±11（P〈0.01）.The whole blood viscosity and plasma viscosity as well as whole blood reduction viscosity were lowered markedly（P〈0.01）.The hematocrit and erythrocyte aggregation index were reduced significantly（P〈0.01）.The erythrocyte deformability was increased（P〈0.01）.The platelet aggregation rate was decreased obviously（P〈0.01）.Conclusion The blood balance therapy significantly improves hemorrheology in the patients with essential hypertension and has good antihypertension effect.

关 键 词：血液平衡 动脉血压 血液流变学 原发性高血压 

分 类 号：R544.1[医药卫生—心血管疾病]