^(177)Lu-DOTMP在荷瘤小鼠体内的生物分布和兔SPECT显像研究  

The Research on Biodistribution of Bearing Sarcoma Mice and Rabbit SPECT Imaging of ^(177)Lu-DOTMP

作　　者：邓新荣[1] 向学琴[1] 李凤林[1] 樊彩云[1] 刘子华[1] 陈阳[2,3] 罗志福[1] 

机构地区：[1]中国原子能科学研究院同位素研究所,北京102413 [2]中国原子能科学研究院 [3]核工业401医院核医学科,北京102413

出　　处：《同位素》2012年第3期160-164,共5页Journal of Isotopes

基　　金：核能开发项目

摘　　要：以1,4,7,10-四氮杂环十二烷和亚磷酸为原料合成了1,4,7,10-四氮杂环十二烷-1,4,7,10-四甲撑膦酸(DOTMP),并对其进行了177 Lu标记;观察了177 Lu-DOTMP在骨转移癌模型鼠体内的生物分布,并对日本大耳白兔进行显像。荷瘤鼠体内的生物分布结果显示:177 Lu-DOTMP可以选择性地在骨组织吸收,具有良好的靶向性,而且在血中清除较快,在其它脏器只有少量的摄取。日本大耳兔显像结果显示:177 Lu-DOT-MP主要聚集于膀胱组织,即177 Lu-DOTMP主要通过肾排泄;注射后22h骨骼放射性摄取明显,46h骨骼中放射性积聚更多。以上结果表明,177 Lu-DOTMP具有良好的骨靶向性,值得进一步研究。Cyclen（1,4,7,10-tetraazacyclododecane） and H3 PO3 were used to synthesis DOT- MP （ 1, 4, 7, 10-tetraazacyclododecane-1, 4, 7, 10-Tetraaminomethylenephosphonate）, and then DOTMP was labelled with 177 Lu. The research of biodistribution of 177 Lu-DOTMP in model mice bearing S180 sarcoma and SPECT imaging in Japanese white rabbit were also carried out. The results of biodistribution of bearing S180 mice indicated that 177 Lu-DOTMP cleared rapidly from blood and was selectively delivered to target bone. The radioactivityuptake was mainly in bone and less in other organs and tissues. The results of SPECT ima- ging of Japanese white rabbit showed that the radioactivity was accumulated in bladder. 177Lu_DOTMP was mainly excreted by kidney. The uptake of the activity in the skeleton was observed significatantly within 22 h post-injection and it became quite significant at 46 h post-injection. It indicated that 177 Lu-DOTMP has good bone targeting and is worthy of fur- ther study.

关 键 词：1 4 7 10-四氮杂环十二烷-1 4 7 10-四甲撑膦酸(DOTMP) 177Lu 荷瘤小鼠 生物分布 日本大耳白兔 SPECT显像 

分 类 号：R817[医药卫生—影像医学与核医学]