阿托伐他汀序贯治疗对行急诊PCI的急性心梗患者心功能的影响  

Atorvastatin sequential therapy improves cardiac function of patients with AMI after primary PCI

作　　者：高宇囡[1] 杨茂[1] 陈延军[1] 公英子[1] 寇世杰 

机构地区：[1]哈尔滨医科大学附属第四医院心内科,黑龙江哈尔滨150001 [2]赤峰医学院附属医院心内科,内蒙古赤峰024000

出　　处：《哈尔滨医科大学学报》2012年第4期360-363,共4页Journal of Harbin Medical University

摘　　要：目的探讨阿托伐他汀序贯治疗对行急诊PCI(primary PCI)的急性心肌梗死(AMI)患者心功能的影响。方法连续随机入选62例24 h内行急诊PCI的AMI患者(男性37例,女性25例),阿托伐他汀序贯治疗者(首剂负荷量80 mg,其后40 mg/d口服4周,继之20 mg/d口服8周)为治疗组,常规治疗剂量者(20 mg/d口服12周)为对照组,对比入院时、第4周及第12周时的左室射血分数(LVEF)、左室舒张末期内径(LVDD)、B型脑钠肽(BNP)及基质金属蛋白酶9(MMP-9)等检测结果。结果①第4周时,治疗组BNP及MMP-9较对照组明显降低(P<0.05);②第12周时治疗组LVEF比对照组明显增高(P<0.05),BNP及MMP-9较对照组显著降低(P<0.01)。结论在行急诊PCI的急性心肌梗死患者中,阿托伐他汀序贯治疗策略对于改善心功能更优于常规治疗方法。Objective To explore the effect of atorvastatin sequential therapy on cardiac func- tion of patients with AMI after primary percutaneous coronary intervention （PCI）. Methods Sixty-two consecutive patients with AMI （37 males and 25 females）were enrolled and all under- went successful primary PCI in the early phase（24 hour）after the onset of AMI. Patients with atorvastatin sequential therapy （ received 80 mg at admission, then 40 mg daily the next 4 weeks and 20 mg daily for the last 8 weeks）were assigned to the atorvastatin group randomly while the others with usual therapy （received 20 mg daily for 12 weeks）were assigned to the control group. The levels of LVEF, LVDD, BNP, and MMP-9 were measured at admission, the 4 th and the 12 th week. Results The atorvastatin sequential therapy resulted in a decrease of BNP and MMP-9 levels at the 4 th week and at the 12 th week. There was an increase of LVEF levels in atorvastatin sequential therapy group compared with the control group at the 12 th week （61.59% ±4. 62% vs 58. 97% ±4. 85% .P =0. 033）. Conclusion The atorvastatin seouential therapy in patients with AMI after primary PCI has better treatment effect than usual therapy.

关 键 词：经皮冠状动脉介入治疗 急性心肌梗死 阿托伐他汀 序贯治疗 

分 类 号：R542.22[医药卫生—心血管疾病]