三黄口服液治疗代谢综合征的疗效观察  

Clinical study of San-Huang Decoction in treating metabolic syndrome men

作　　者：刘庆丰[1] 李中东[1] 施孝金[1] 钟明康[1] 

机构地区：[1]复旦大学附属华山医院临床药学研究室,上海200040

出　　处：《中药药理与临床》2012年第4期104-106,共3页Pharmacology and Clinics of Chinese Materia Medica

基　　金：上海市卫生局资助课题:三黄口服液治疗代谢综合症中心性肥胖的临床观察与开发(No.2010Y007A)

摘　　要：目的:探讨三黄口服液对代谢综合征肥胖人群的临床疗效。方法:以20名健康志愿者为参照,将100名代谢综合征患者随机分为治疗组(60名)和安慰剂组(40名),分别予三黄口服液和安慰剂治疗12周,观察治疗前后患者心血管危险因素的变化。结果:与安慰剂组相比,治疗组(起效剂量为10 ml/人,黄连素浓度为0.16～0.22 mg/ml)除空腹血糖,甘油三酯在治疗前后无显著差异外,腰围、体质量指数、腰臀围比值、胰岛素抵抗指数,血清C反应蛋白水平、游离脂肪酸明显改善,差异有显著性(P<0.05);随着腰围的增大,男性的糖代谢异常、高血压病、血脂紊乱及代谢综合征的发生率均呈现增高趋势(P<0.01)。结论:三黄口服液可明显降低代谢综合征人群肥胖和胰岛素抵抗程度,并能改善炎症状态,减轻致心血管病的危险性。Objective： To study the therapeutic effects of San-Huang Decoction, a Chinese medicine preparation, on metabolic syndrome men. Methods： Compared with 20 healthy male volunteers, 100 metabolic syndrome men were separated randomly into two groups and received the interventions with San-Huang Decoction and placebe respectively for 12 weeks. Baseline characteristics, insulin resistance and inflammation cytokines were evaluated before and after treatment. Results： After treatment, compared with placebo group, body mass index, waist, and waist-to-hip ratio, insulin resistance, C-reactive protein, free fatty acid were decreased significantly in subjects who received San-Huang de- coction （P 〈 0.05）, while fasting blood glucose and triglyceride hardly changed. With the increase of waist circumference, the incidence of abnormal glucose metabolism, hypertension, dyslipidemia and metabolic syndrome showed an increasing tendency （ P 〈 0.01 ）. Conclusion： San-Huang can reduce insulin resistance in metabolic syndrome men and improve inflammation and fibrinolysis, which indicates that it can re- duce the risk of cardiovascular disease.

关 键 词：三黄口服液 代谢综合征 疗效 心血管 危险因素 

分 类 号：R285[医药卫生—中药学]