多梗死性脑痴呆模型研制与中药药效评价思考  

Advances in establishments of animal models with MID and thinking about efficacy evaluation of TCM

作　　者：栾永福[1,2] 李晓骄阳 孙蓉[1] 

机构地区：[1]山东省中医药研究院,济南250014 [2]天津中医药大学,天津300073 [3]中国药科大学药学院,南京211198

出　　处：《中药药理与临床》2012年第4期121-124,共4页Pharmacology and Clinics of Chinese Materia Medica

基　　金：国家重大新药创制重大专项:中药药理学研究与药效评价关键技术研究(2009ZX09502-015);山东省人事厅山东省博士后创新项目:芍药苷对多梗塞性痴呆神经原损伤的体内保护作用(200801002);山东省重大新药创制综合性大平台中药单元平台中药药理与毒理子平台建设(2009ZX09301-013)

摘　　要：多发梗塞性脑痴呆动物模型对于探求多发梗塞性脑痴呆疾病的病理机制、药物筛选、药效评价以及治疗方案优化有十分重要的作用。故建立具有较强稳定性,能够反映特定病理生理变化的多发梗塞性脑痴呆动物模型一直是研究者追求的目标,目前建立了许多模拟人类多发梗塞性脑痴呆疾病的实验动物模型。根据中药自身的特点选择合适的动物模型,进行候选药物筛选和药效评价,并将多发梗塞性脑痴呆动物模型的研究与临床疾病研究紧密地结合起来,保证动物模型的稳定性和可靠性,为临床前中药药理研究与药效评价提供方法学保证,为有效的中药创新药物筛选与研发评价提供研究工具,以确保有效药物在临床上获得更好的疗效。Animal model with multi-infarct dementia is quite important to search after the pathological mechanism, medicine screening, efficacy e- valuation and optimizing therapeutic schedule of MID. It is researchers＂ aim to estabhsh MID animal model of strong stability and that can re-flect specific pathological and physiological change. We should select suitable animal model on the basis of TCM＇s characteristic to screen out medicine and to evaluate the efficacy of medicine, and combine closely the research of MID＇s animal model with clinical disease to ensure the stability and reliability of animal model. And then to offer methodological esufience guarantee for TCM＇s pharmacological preclinical research and efficacy evaluation as well as to offer research tools for screening effective new TCM and evaluating research, then to ensure the better clinical curative effect of the effective medicine.

关 键 词：多发梗塞性脑痴呆 动物模型 药效评价 

分 类 号：R285[医药卫生—中药学]