健心颗粒对慢性心力衰竭患者心功能及心肌基质的影响  

Effect of Jianxin granule on cardiac function and myocardial substrate in patients with chronic heart failure

作　　者：曾凯[1] 苗丽娜[1] 王永[1] 陈美华[1] 欧阳秋芳[2] 

机构地区：[1]福建中医药大学附属福建省第二人民医院心内科,福州市350003 [2]福建中医药大学附属福建省第二人民医院超声科,福州市350003

出　　处：《中华实用诊断与治疗杂志》2012年第10期979-980,983,共3页Journal of Chinese Practical Diagnosis and Therapy

基　　金：福建省教育厅科技项目(JA10178);福建省教育厅科技项目(JA08128)

摘　　要：目的评价健心颗粒对慢性心力衰竭患者心功能及心肌基质的影响。方法 90例慢性心力衰竭患者,随机分为福辛普利组45例(福辛组)与福辛普利加健心颗粒组45例(健心组),采用NYHA心功能分级标准评价2组患者治疗前、后心功能,采用ELISA法测量2组患者血清基质金属蛋白酶(matrix metalloproteinase,MMP)-2,MMP-3,MMP-9及组织金属蛋白酶抑制物-1(tissue inhibitor of metalloproteinase,TIMP-1)水平。结果慢性心力衰竭患者血清MMPs水平与左心室射血分值呈负相关;血清TIMP-1水平与左心室射血分数值呈正相关;福辛组治疗后左心室射血分数值、血清MMP-2,MMP-3,MMP-9及TIMP-1水平与治疗前比较差异无统计学意义(P>0.05);健心组治疗后左心室射血分数及血清TIMP-1水平明显高于治疗前(P<0.05),血清MMP-2,MMP-3,MMP-9水平明显低于治疗前(P<0.05)。结论健心颗粒可通过改善心肌基质而提高慢性心力衰竭患者的心功能。Objective To assess the effect of Jianxin granule on cardiac function and myocardial substrate in patients with chronic heart failure （CHF）. Methods A total of 90 patients with CHF were randomly divided into fosinopril group （n=45） and Jianxin group receiving fosinopril and Jianxin granule （n= 45）. The cardiac function was assessed with the New York Heart Association （NYHA） functional classification. The levels of serum matrix metalloproteinase （MMP） 2, MMP-3, MMP-9 and tissue inhibitors of metalloproteinase 1 （TIMP-1） were determined with enzyme-linked immunosorbent assay （ELISA）. Results Serum MMP level was negatively and serum TIMP-1 level was positively correlated with left ventricular ejection fraction （LVEF） in CHF patients. There were no significant differences in LVEF, serum MMP level or TIMP-1 level before and after treatment in fosinopril group. The levels of LVEF and TIMP-1 were significantly higher and the levels of serum MMP-2, MMP-3 and MMP-9 were significantly lower after the treatment than those before treatment in Jianxin group （P〈0.05）. Conclusion Jianxin granule could significantly improve cardiac function by ameliorating myocardial substrate.

关 键 词：慢性心力衰竭 心肌重构 健心颗粒 基质金属蛋白酶 组织金属蛋白酶抑制物-1 

分 类 号：R259[医药卫生—中西医结合]