垂体后叶素、乌拉地尔联合治疗急诊中重度咯血患者的临床疗效观察  

Clinnical Observation of Pituitrin with Urapidil Treat the Emergency Moderate and Severe Hemooptysis

作　　者：保学明[1] 黄国孟[1] 黎靖麟[1] 

机构地区：[1]广东省广州市第一人民医院急诊科,510180

出　　处：《实用心脑肺血管病杂志》2012年第10期1622-1623,共2页Practical Journal of Cardiac Cerebral Pneumal and Vascular Disease

摘　　要：目的探讨乌拉地尔、垂体后叶素联合治疗急诊中、重度咯血患者的效果。方法 90例急诊中重度咯血患者随机分为垂体后叶素组、乌拉地尔组和联合治疗组。垂体后叶素组给予垂体后叶素5U缓慢静脉滴注,后用垂体后叶素10U加入500ml的0.9%氯化钠溶液,以0.1～0.2U/min速度24h持续静脉滴注。乌拉地尔组单用乌拉地尔100～400mg加入500ml的0.9%氯化钠溶液中以0.25～1mg/min速度持续静脉滴注。联合治疗组使用垂体后叶素5U缓慢静脉滴注,继以垂体后叶素10U加入500ml的0.9%氯化钠溶液中以0.1～0.2U/min速度静脉滴注,同时给予乌拉地尔100～400mg加入500ml的0.9%氯化钠溶液中以0.25～1mg/min速度持续静脉滴注。治疗时间为24h,观察3组24h内咯血缓解时间、不良反应发生率。结果联合治疗组、垂体后叶素组、乌拉地尔组总有效率分别为83.3%、60.0%、53.3%,联合治疗组与垂体后叶素组、乌拉地尔组比较,差异均有统计学意义(P<0.05);不良反应发生率分别为10.0%、46.6%、26.6%,联合治疗组与垂体后叶素组比较,差异均有统计学意义(P<0.05);咯血减少平均时间分别为(4.88±1.82)h、(9.89±1.84)h、(13.19±1.88)h,联合治疗组与垂体后叶素组、乌拉地尔组比较,差异均有统计学意义(P<0.01)。结论联合治疗急诊大咯血具有起效快,不良反应少,应用患者范围广等特点。Objective To investigate the effect of pituitrin with urapidil treat the moderat and severe hemoptysis for e- mergency patients. Methods Ninety moderate and severe eases of hemoptysis were randomized into pituitrin group, urapidil groupand combining treatment group. The time of therapeutic observation were 24 hours, to study remittent time and incidence rate effect in 3 groups for 24 hours. Results In the combining treatment group, pituitrin group and urepidil group, the total ef- fective rate were 83.3%, 60% and 53.3% （P 〈 0. 05）, the incidence rate of side effects were 10%, 46. 6% and 26. 6% （ P 〈0. 05）, and the average time of hemoptysis decrease were （4. 88±1.82） h, （9. 89±1.84） h, （ 13. 19±1.88） h （P 〈 0. 01 ）. Conclusion Combining treatment can cure hemoptysis rapidly, and has less side effect and extensive application for pa- tients.

关 键 词：垂体激素类 后叶 乌拉地尔 咯血 

分 类 号：R441.6[医药卫生—诊断学]