环亚胺毒素研究进展  

Research progress of cyclic imines toxins

作　　者：吴海燕[1] 郭萌萌[1] 谭志军[1] 李兆新[1] 翟毓秀[1] 

机构地区：[1]农业部水产品质量安全检测与评价重点实验室,中国水产科学研究院黄海水产研究所,国家水产品质量监督检验中心,山东青岛266071

出　　处：《中国渔业质量与标准》2012年第3期21-32,共12页Chinese Fishery Quality and Standards

基　　金：国家自然科学基金项目(41106109);中央级基本科研业务费专项资金资助项目(20603022011004);国家海洋局海洋生态与海洋生物地球化学重点实验室开放基金资助(LMEB201004)

摘　　要：环亚胺(Cyclic imines,CIs)毒素是一种"快速作用毒素",通过小鼠腹腔注射迅速致死。不仅存在于藻毒素中,贝类自身代谢也可产生,给水产品质量安全带来严重威胁。本文就该毒素的化学组分与结构、生物转化、致毒机理、分析方法等国内外最新研究进展和政策变化进行系统的论述,提出我国的应对措施,为我国的赤潮监控和贝类安全监测提供资料参考。Cyclic imines （CIs） are a recently discovered group of marine biotoxins characterized by their fast acting toxicity, inducing a characteristic rapid death in the intraperitoneal mouse bioassay. Some of these toxins are not only present in algae but also result from metabolism within the shellfish, which lead to great threat to the quality and safety of aquatic products. An extensive review of different aspects of cyclic imines were presented including chemical structures, toxin transformation, mechanism of action and analytical methods of the toxins, which could provide proposed measures to the monitoring of red tide and shellfish safety. [ Chinese Fishery Quality and Standards, 2012, 2（3 ） ：21 -32]

关 键 词：环亚胺毒素 分析方法 致毒机理 急性毒性实验 液相色谱串联质谱法 

分 类 号：X830[环境科学与工程—环境工程]