卵泡输出率与体外受精-胚胎移植中卵巢反应性的研究  

Study on the follicular output rate and ovarian response in the IVF-ET patients

作　　者：梅巳[1] 徐仙[2] 刘春莲[2] 赵君利[2] 胡蓉[2] 马小红[2] 哈灵侠[2] 

机构地区：[1]宁夏医科大学,宁夏银川750001 [2]宁夏医科大学总医院生殖医学中心,宁夏银川750004

出　　处：《宁夏医学杂志》2012年第9期839-841,共3页Ningxia Medical Journal

摘　　要：目的探讨卵泡输出率(FORT)对实施体外受精-胚胎移植(IVF-ET)患者卵巢反应性及妊娠结局的预测效力。方法按FORT值将200个IVF-ET患者分为高、低2组,回顾性分析2组间控制性超排卵数据及实验室指标。结果高FORT值组降调后窦卵泡数少于低FORT值组[(10.9±3.5)与(11.1±6.2)个,P<0.001],而HCG日E2水平明显高于低FORT值组[(2 701.2±102)与(2 183±86)pg/ml,P<0.001)],但2组间基础FSH及E2水平、促性腺激素总量及排卵前卵泡数差异无统计学意义(P>0.05)。高FORT值组获卵数(11.8±0.6)与(8.6±0.4)个;MⅡ卵数(10.0±0.6)与(7.4±0.4)个;可移植胚胎数(7.4±0.4)与(5.7±0.3)个;胚胎种植率37.7%与23.3%;临床妊娠率62.8%与33.8%,均高于低FORT值组(P<0.05)。结论 FORT可有效地预测IVF-ET过程中卵巢的反应性,高FORT值患者将具有更好的妊娠结局。Objective To evaluate if the follicular output rate （FORT） is an effective parameter for predicting the ovarian response in IVF - ET. Methods 200 IVF - ET patients were divided into two groups according to their FORT. The parameters of the controlled ovarian hyperstimulation and IVF - ET between these two groups were retrospectively analyzed. Results The antral follicle count of the high FORT group after pituitary desensitization was less than the low FORT group （ 10.9 ± 3.5 vs. 11.1± 6.2,P 〈0. 001 ）. However, the concentration of serum E2 on the day of HCG was significantly higher in the high FORT group （2701.2 ± 102 vs. 2183± 86, P 〈0.1301 ）. There were no differences about the basal FSH, basal E2, the total gonadotropin dosage and the preovulatory follicle count （ all P 〉0. 05 ） between two groups. The oocytes retrieved number （ 11.8±0. 6 vs. 8.6 ±0. 4, P 〈 0. 001 ）, M 11 oocytes number （ 10.0 ± 0.6 vs. 7.4 ±0. 4, P 〈 0. 001 ）, embryos obtained number （7.4 ±0. 4 vs. 5.7 vs 0.3, P 〈 0. 002）, the embryo implantation rate （37.7% vs. 23.3% , P 〈0. 004） and clinical pregnancy rate （62.8% vs. 33.8% , P 〈 0. 004） were remarkably higher in the high FORT group. Conclusion The study suggests that FORT may be a qualitative reflector of ovarian follicular competence and ovarian response. IVF -ET candidates with moderately high FORT may have more chances for pregnancy.

关 键 词：卵泡输出率 卵巢反应性 控制性超排卵 窦卵泡 体外受精-胚胎移植 

分 类 号：R714.8[医药卫生—妇产科学]