血清TIgE、SPT和IOS测定在儿童咳嗽变异型哮喘中的临床意义  

Analyzing clinical significance of total IgE,skin prink test in serum and impulse oscillometry for lung function measurements in children with cough variant asthma

作　　者：吴立强[1] 陈建平[1] 何念海[1] 桂芹[1] 王梅[1] 

机构地区：[1]第三军医大学西南医院儿科,重庆400038

出　　处：《重庆医学》2012年第29期3043-3045,共3页Chongqing medicine

基　　金：国家自然科学基金资助项目(30600686);重庆市自然科学基金资助项目(CSTC2007BB5062)

摘　　要：目的探讨皮肤点刺、血清总IgE和脉冲振荡肺功能测定在学龄前儿童咳嗽变异型哮喘中的作用。方法分别测定并比较100例咳嗽变异型哮喘患儿,102例支气管哮喘患儿及同期本院体检的105例健康儿童血清总IgE水平、皮肤点刺结果和脉冲振荡肺功能结果。结果 (1)CVA组、哮喘组患儿吸入性变应原、摄入性变应原、尘螨阳性率、总变应原阳性率和总IgE比较显著高于健康组(P<0.01),CVA组与哮喘组比较差异无统计学意义。(2)脉冲振荡肺功能检测显示CVA组和哮喘组的呼吸总阻抗(Zrs)、总呼吸黏性阻力(R5)、中心气道黏性阻力(R20)、周边气道黏性阻力(R5-R20)及共振频率(Fres)均高于对照组(P<0.05);CVA组的Zrs、R5、R20、R5-R20、Fres均低于哮喘组(P<0.05)。结论检测皮肤点刺、血清总IgE水平和脉冲振荡肺功能有助于了解学龄前儿童咳嗽变异性哮喘气道炎症变化及气道阻塞情况。Objective To study the role of skin prick test,serum total IgE and impulse oscillometry for lung function measurements in preschool children which with cough variant asthma（CVA）. Methods Total IgE in serum,skin prink test and impulse oseillometry for lung function measurements were detected in 100 patients with CVA, 102 with bronchial asthma and 105 of healthy children received medical examination in our hospital（controls）. Results （1） The positive rates of inhaled allergen, food allergen, dust mite, total allergen and total IgE levels in the CVA and asthma groups were higher than those in the control group（P〈0.01）. However,no siginifieant difference were three among the two case groups. The impulse oscillometry demonstrated that the respiretory total impedance （Zrs）, airway resistance at 5 Hz （RS）, airway resistance at 20 Hz （R20）, subtracting R5 from R20 （R5-R20） and resonant frequency（Fres） in the CVA and asthma were higher than those in the control group（P〈0. 05）. Zrs, R5, R20, RS-R20,and Fres in the CVA were lower than those in the asthma group（P;0.05）. Conclusion The measurements of skin prink test,total IgE and impulse oscillometry for lung function are helpful for the evaluation of airway inflammation and airway obstruction in preschool children with CVA.

关 键 词：咳嗽变异型哮喘 皮肤点刺 免疫球蛋白E 脉冲振荡肺功能 儿童 

分 类 号：R725.6[医药卫生—儿科]