刺五加注射液治疗出血性中风急性期随机对照试验的系统评价  

A Systematic Review of Acanthopanex Injection for Acute Ischaemic Stroke

作　　者：马丽虹[1] 李冬梅[2] 李可建[1] 

机构地区：[1]山东中医药大学,山东济南250355 [2]山东省济南市中医医院,山东济南250011

出　　处：《中国中医急症》2012年第9期1441-1442,1448,共3页Journal of Emergency in Traditional Chinese Medicine

基　　金：国家自然基金委资助课题(30801458)

摘　　要：目的系统评价刺五加注射液治疗出血性中风急性期的疗效及安全性。方法检索刺五加注射液治疗出血性中风急性期随机对照试验,筛选合格研究,应用Jadad评分法进行质量评价,运用异质性检验、Meta分析等统计相关数据。结果 10项研究符合选择标准,所有研究Jadad评分均低于3分。Meta分析结果显示,总有效率比较的相对危险度(99%的CI)为1.30(1.12,1.51),神经功能缺损评分比较的加权均数差(WMD)(99%的CI)为-3.69(-4.72,-2.65),出血量比较的WMD(99%的CI)为-2.63(-4.21,-1.04)。结论 Meta分析结果显示刺五加注射液具有改善出血性中风急性期患者神经功能缺损状况、减少出血量的作用,且安全性较高。Objective： To evaluate efficacy and safety of acanthopanex injection for acute ischaemic stroke. Methods： Randomized controlled trails （RCTs） of acanthopanex injection for acute ischaemic stroke were identi- fied. Eligible studies were included. The methodological quality of inclusive trails was assessed by Jadad scale. Heterogeneity test, Meta-analysis ,funnel plot analysis and sensitivity analysis were used to analyse data. Results： 10 RCTs were included whose Jadad scores were less than 3. Meta analysis indicated that relative risk of overall effective rate was 1.30 [ 99% CI （ 1.12,1.51 ） ]. WMD （99% CI） of neural function defect score was -3.69 （-4.72, - 2.65）. WMD （99%CI）of bleeding volume was -2.63 （-4.21 ,-1.04）. Conclusion： This systematic review shows that acanthopanex injection is effective and safe for acute ischaemic stroke. It do not only improve the neurologic function deficits, but also decrease the bleeding volume.

关 键 词：刺五加注射液 中风 出血性急性期 随机对照 试验系统评价 

分 类 号：R255.2[医药卫生—中医内科学]