气体发泡PLA/PS共混高聚物制备组织工程支架研究  

Study of Tissue Engineering Scaffolds Fabricated by Polymer Blends with Gas Foaming PLA/PS Blends

作　　者：周长春[1] 马梁[2] 董志红[3] 

机构地区：[1]四川大学国家生物医学工程研究中心,四川成都610044 [2]华盛顿大学机械工程系,美国西雅图981952600 [3]成都大学工业制造学院,四川成都610106

出　　处：《成都大学学报（自然科学版）》2012年第3期203-207,共5页Journal of Chengdu University（Natural Science Edition）

基　　金：国家基础研究计划("973"计划)(2011CB606201)资助项目

摘　　要：相互联通的三维可控孔隙结构是组织工程支架材料设计的关键.介绍了一种通过气体物理发泡工艺制备多孔生物支架材料的方法,研究了对不可共混的双相高分子材料聚乳酸与聚苯乙烯进行可控发泡的设计,发泡后经溶蚀工艺处理得到相互联通的孔隙结构.成骨细胞种植实验结果显示,细胞在支架中生长情况良好,经2周培养初步表现出在三维空间蔓延传递生长的特征,表明此方法为制备三维可控多孔类组织工程支架材料提供了一种有效设计途径.Interconnected 3-D perous structure plays a critical role in tissue engineering scaffolds. A novel approach to fabricate porous tissue engineering scaffolds by gas foaming method was proposed. The immisci- ble polymer blends consisting of polylactic acid （PLA） and polystyrene （PS） were used to control the de- sign. The interconnected porous structure was created by the extracting process. The fabricated porous scaf- folds were used to culture human osteoblast cells. The findings of osteoblasts cultivation experiment indicate that the cells {Vow well in the scaffolds. After 2 weeks＇ culture, the cells migrate and propagate along the porous structures in a 3-D space. The experiment shows that this method provides a promising way of fabri- cating controllable interconnected porous polymers for tissue engineering.

关 键 词：不可共混高聚物 气体物理发泡 组织工程支架 成骨细胞 聚乳酸 

分 类 号：TQ325[化学工程—合成树脂塑料工业] R318.08[医药卫生—生物医学工程]